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Title Genome-based therapeutics : targeted drug discovery and development : workshop summary / Adam C. Berger and Steve Olson, Rapporteurs ; Roundtable on Translating Genomic-Based Research for Health, Board on Health Sciences Policy, Institute of Medicine of the National Academies.

Publication Info. Washington, District of Columbia : National Academies Press, [2012]


Location Call No. OPAC Message Status
 Axe ProQuest E-Book  Electronic Book    ---  Available
Description 1 online resource (109 pages) : illustrations
text rdacontent
computer rdamedia
online resource rdacarrier
Bibliography Includes bibliographical references (pages 55-57).
Contents Introduction -- The current landscape -- Case studies: The development of Crizotinib for treatment of non-small-cell lung cancer; Use of genetics to inform drug development for the treatment of schizophrenia; A genetic approach to the treatment of cystic fibrosis -- Emerging technologies in drug development: Large-scale whole-genome sequencing; The value of clinical next-generation sequencing to drug developers; The uses of genomic information -- Evolving paradigms: Foundations and drug development: an example; Genomics and regulatory science; Pharmacy benefit management and pharmacogenomics; Repurposing of drugs -- Forging collaborative strategies for the development of personalized medicine: The need for collaboration; FDA initiatives; NCATS initiatives; Biospecimens and databases; Reducing health disparities; Patient and physican education; An emphasis on the science.
Summary "The number of new drug approvals has remained reasonably steady for the past 50 years at around 20 to 30 per year, while at the same time the total spending on health-related research and development has tripled since 1990. There are many suspected causes for this trend, including increases in regulatory barriers, the rising costs of scientific inquiry, a decrease in research and development efficiency, the downstream effects of patient expirations on investment, and the lack of production models that have successfully incorporated new technology. Regardless, this trajectory is not economically sustainable for the businesses involved, and, in response, many companies are turning toward collaborative models of drug development, whether with other industrial firms, academia, or government. Introducing greater efficiency and knowledge into these new models and aligning incentives among participants may help to reverse the trends highlighted above, while producing more effective drugs in the process. Genome-based therapeutics explains that new technologies have the potential to open up avenues of development and to identify new drug targets to pursue. Specifically, improved validation of gene-disease associations through genomics research has the potential to revolutionize drug production and lower development costs. Genetic information has helped developers by increasing their understanding of the mechanisms of disease as well as individual patients' reactions to their medications. There is a need to identify the success factors for the various models that are being developed, whether they are industry-led, academia-led, or collaborations between the two. Genome-Based Therapeutics summarizes a workshop that was held on March 21, 2012, titled New paradigms in drug discovery: how genomic data are being used to revolutionize the drug discovery and development process. At this workshop the goal was to examine the general approaches being used to apply successes achieved so far, and the challenges ahead"--Publisher's description.
Note Description based on print version record.
Subject Drugs -- United States -- Design -- Congresses.
Pharmaceutical technology -- United States -- Congresses.
Pharmaceutical industry -- United States -- Congresses.
Genomics -- United States -- Congresses.
Genre/Form Electronic books.
Added Author Berger, Adam C., contributor.
Olson, Steve, 1956- contributor.
Institute of Medicine (U.S.). Roundtable on Translating Genomic-Based Research for Health, issuing body.
Institute of Medicine (U.S.). Board on Health Sciences Policy, issuing body.
Added Title Targeted drug discovery and development
Other Form: Print version: Genome-based therapeutics : targeted drug discovery and development : workshop summary. Washington, District of Columbia : National Academies Press, [2012] xx, 89 pages ; 23 cm. 9780309260213 (OCoLC)ocn824457733 (DLC) 2012554410
ISBN 9780309260244
9780309260251 (e-book)

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