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Title Advanced textbook on gene transfer, gene therapy, and genetic pharmacology : principles, delivery, and pharmacological and biomedical applications of nucleotide-based therapies / editor, Daniel Scherman.

Publication Info. London : Imperial College Press, [2014]


Location Call No. OPAC Message Status
 Axe EBSCO Clinical Nursing E-Book  Electronic Book    ---  Available
Description 1 online resource (xi, 544 pages) : color illustrations.
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series ICP Textbooks in Biomolecular Sciences, 2045-0281 ; Volume 1
ICP textbooks in biomolecular sciences ; 1.
Bibliography Includes bibliographical references at the end of each chapters and index.
Note Print version record.
Contents pt. I. Basic definitions and principles. ch. 1. Introduction / Thierry VandenDriessche -- ch. 2. Basic definitions and general principles / Daniel Scherman -- ch. 3. History of gene therapy / Serge Braun -- ch. 4. Genetic pharmacology using synthetic deoxyribonucleotides / Jean-Christophe Francois and Carine Giovannangeli -- ch. 5. Principles of RNAi trigger expression for gene therapy / Lisa J. Scherer and John J. Rossi -- ch. 6. On demand alternative splicing for gene rescue / Stephanie Lorain and Luis Garcia -- ch. 7. Nuclease-mediated targeted genetic correction / Dieter C. Gruenert, Hamid Emamekhoo and R. Geoffrey Sargent -- pt. II. Vectors and gene delivery techniques. ch. 8. [symbol]-retrovirus- and lentivirus-derived vectors for gene transfer and therapy / Caroline Duros and Odile Cohen-Haguenauer -- ch. 9. Adenovirus vectors / Stefan Kochanek -- ch. 10. Adeno-Associated Virus (AAV) vectors / Aurelie Ploquin, Hildegard Buning and Anna Salvetti -- ch. 11. Herpes Simplex Virus (HSV-1)-based vectors: Applications for gene transfer, gene therapy, cancer virotherapy and vaccination / Matias E. Melendez [and others] -- ch. 12. Non-viral DNA vectors / Martin Schleef -- ch. 13. Macromolecular conjugates for non-viral nucleic acid delivery / Mark Ericson, Kevin Rice and Guy Zuber -- ch. 14. Auto-associative lipid-based systems for non-viral nucleic acid delivery / Virginie Escriou, Nathalie Mignet and Andrew Miller -- ch. 15. Hydrodynamic-pressure-based non-viral nucleic acid delivery / Takeshi Suda -- ch. 16. Electrotransfer/electroporation for non-viral nucleic acid delivery / Pascal Bigey, Richard Heller and Daniel Scherman -- ch. 17. Imaging of gene delivery / Georges Vassaux [and others] -- pt. III. Therapeutic applications. ch. 18. Oncolytic adenoviruses for cancer gene therapy / Gunnel Hallden [and others] -- ch. 19. Progress in DNA vaccine approaches for cancer immunotherapy / Geoffrey D. Hannigan and David B. Weiner -- ch. 20. Gene therapy of the beta-hemoglobinopathies / Emmanuel Payen [and others] -- ch. 21. Gene therapy for hemophilia A and B / Nisha Nair, Marinee Chuah and Thierry VandenDriessche -- ch. 22. Experimental and clinical ocular gene therapy / Alexis-Pierre Bemelmans and Jose-Alain Sahel -- ch. 23. Gene therapy of neurological diseases / Lisa M. Stanek, Lamya S. Shihabuddin and Seng H. Cheng -- ch. 24. Genetic therapy of muscle diseases: Duchenne muscular dystrophy / Takis Athanasopoulos [and others] -- ch. 25. Induced pluripotent stem cells and gene targeting for regenerative medicine / Jizhong Zou and Linzhao Cheng -- pt. IV. Gene vector production. ch. 26. Production and purification of viral vectors and safety considerations related to their use / Otto-Wilhelm Merten [and others] -- ch. 27. Production and purification of plasmid vectors / Martin Schleef.
Summary This unique advanced textbook provides a clear and comprehensive description of the field of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of revolutionary gene therapy strategies. In this advanced textbook, more than 25 leading scientists, world-renowned in their respective fields, come together to provide a clear and comprehensive description of gene delivery, gene therapy and genetic pharmacology. This educational introduction to the main gene transfer vectors and selected therapeutic applications provides the background material needed to further explore the subject as well as relevant research literature. It will thus be invaluable to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide, or develop a gene therapy strategy. Furthermore, the textbook's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Subject Genetic transformation.
Gene therapy.
MEDICAL -- Pharmacology.
Gene therapy. (OCoLC)fst00939638
Genetic transformation. (OCoLC)fst00940104
Genre/Form Electronic books.
Added Author Scherman, Daniel, editor.
Other Form: Print version: Advanced textbook on gene transfer, gene therapy, and genetic pharmacology. New Jersey : Imperial College Press, 2013 9781848168282 (DLC) 2013008317 (OCoLC)828858980
ISBN 9781848168305 (electronic bk.)
1848168306 (electronic bk.)
Standard No. DEBBG BV043029385
DEBSZ 446477389

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