| Description |
1 online resource (xvii, 399 pages, 16 unnumbered pages of plates) : illustrations (some color |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Cambridge medicine |
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Cambridge medicine (Series)
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| Bibliography |
Includes bibliographical references and index. |
| Summary |
"The first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine. This book will be an invaluable resource for sleep specialists, neurologists, geneticists, psychiatrists and psychologists"--Provided by publisher |
| Note |
Print version record. |
| Contents |
Foreword; Preface; Contributors; Abbreviations; Section 1 General principles of genetics and genomics; Chapter 1 Linkage and associations; Introduction; Linkage; Linkage results in narcolepsy-cataplexy; Linkage results in familial advanced sleep phase syndrome (FASPS); Linkage results in restless leg syndrome; Complex phenotypes; Methodology in studying complex phenotypes; Genome-wide association studies in sleep and sleep-related disorders; Sleep diseases as dichotomous traits; Sleep as a quantitative trait; Conclusion; References. |
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Chapter 2 Methods in complex trait analysis: mapping the genetic basis of sleep using model organismsIntroduction; Inbred strains; Genetic mapping using crosses between inbred strains; Genetic mapping without genotyping: recombinant inbreds and the collaborative cross; Genetic mapping without genotyping: recombinant congenics and consomics; Genetic mapping without genotyping: in silico mapping; Genetic mapping without genotyping: the hybrid mouse diversity panel; High-resolution mapping and gene identification: congenics, AILs, and outbreds; Sequencing; A wealth of choice; References. |
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Chapter 3 Genome-wide association study (GWAS) approaches to sleep phenotypesIntroduction; Genes associated with sleep-wake regulation; Genetics of sleep disorders; Restless legs syndrome; Narcolepsy; Insomnia; Sleep apnea; Conclusions; References; Section 2 Genetics of sleep and circadian rhythms; Chapter 4 Genetic epidemiology of sleep and sleep disorders; Introduction; Methods in genetic epidemiology; Normal sleep; Sleep electroencephalogram (EEG) and polysomnography (PSG); Diurnal type; Sleep length; Sleep quality; Abnormal sleep, sleepiness and sleep disorders; Insufficient sleep. |
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Daytime sleepinessSleep problems; Insomnia; Obstructive sleep apnea (OSA); Narcolepsy; Parasomnias; Arousal disorders; Sleep-wake transition disorders; Parasomnias usually associated with REM sleep; Other parasomnias; Is there a common genetic basis to parasomnia?; Restless legs syndrome (RLS); Conclusions; References; Chapter 5 Drosophila model systems for genetic sleep research; In the beginning: using a candidate gene approach for studying sleep in Drosophila; Interpreting results from genetic studies; Short-term memory; Long-term memory; Unbiased screens. |
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Circuits regulating sleep in DrosophilaMushroom bodies; Pars intercerebralis; Ventral lateral neurons; Octopamine-expressing neurons; Dorsal fan-shaped body; Dopamine-expressing neurons; Forward genetic screens; Mutant screens; Minisleep and Shaker; Sleepless; Insomniac; Cyclin A; Plasticity; Summary; References; Chapter 6 Caenorhabditis elegans and zebrafish in sleep research; Behavioral approach to identify and study sleep; Zebrafish sleep; Behavior; Anatomy; Pharmacology; Genetics; C. elegans sleep; C. elegans sleep genetics; Mechanism of sensory gating during sleep in C. elegans. |
| Language |
English. |
| Subject |
Sleep disorders.
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Sleep -- genetics |
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Sleep Wake Disorders -- genetics |
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Sleep Wake Disorders. |
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Troubles du sommeil.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Sleep disorders
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| Added Author |
Shaw, Paul, 1963-
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Tafti, Medhi.
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Thorpy, Michael J.
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| Other Form: |
Print version: 9781107041257 1107041252 (DLC) 2013014823 |
| ISBN |
1107417457 (electronic bk.) |
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9781107417458 (electronic bk.) |
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9781139649469 (electronic bk.) |
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1139649469 (electronic bk.) |
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9781107420069 |
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1107420067 |
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9781107645615 (paperback) |
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1107645611 |
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9781107041257 (hardback) |
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1107041252 (hardback) |
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1107440688 |
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9781107440685 |
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1107425387 |
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9781107425385 |
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1107423155 |
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9781107423152 |
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1107421381 |
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9781107421387 |
| Standard No. |
AU@ 000066767617 |
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DEBBG BV042794873 |
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