| Description |
1 online resource (xii, 500 pages) : illustrations (some color) |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Advances in magnetic resonance technology and applications ; volume 9 |
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Advances in magnetic resonance technology and applications ; v. 9
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| Bibliography |
Includes bibliographical references and index. |
| Contents |
Intro -- Imaging Neuroinflammation -- Copyright -- Contents -- List of contributors -- Preface -- Part 1: Overview -- Chapter 1: Molecular and tissue basis of neuroinflammation in health and disease -- General introduction -- Peripheral inflammation -- The case of neuroinflammation -- Blood-brain barrier alterations -- Increased blood-brain barrier permeability induced by inflammation -- Pathological substrate -- Introduction to BBB permeability-associated imaging biomarkers -- Entrance of inflammatory cells across the inflamed blood-brain barrier -- Pathological substrate |
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Introduction to immune cell infiltration-associated imaging biomarkers -- Edematous component associated with inflammation -- Pathological substrate -- Introduction to edema-associated imaging biomarkers -- Inflammatory activation of microglia and astrocytes -- Pathological substrate -- Introduction to microglia and astrocyte-associated imaging biomarkers -- Inflammatory attack on myelin -- Pathological substrate -- Introduction to myelin-associated imaging biomarkers -- Neuronal injury -- Pathological substrate -- Introduction to neuronal-associated imaging biomarkers -- Iron |
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Pathological substrate -- Introduction to iron-associated imaging biomarkers -- Conclusion -- References -- Part 2: Imaging approaches to inflammation -- Chapter 2: Sensitivity and specificity of diffusion MRI to neuroinflammatory processes -- What is diffusion MRI? -- Sensitivity of diffusion MRI to cellular inflammatory processes -- Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) -- Sensitivity of DTI and DKI to neuroinflammation -- Animal validation studies showing sensitivity of diffusion MRI to neuroinflammation -- Human studies of neuroinflammation using DTI and DKI |
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Specificity of diffusion MRI to cellular inflammatory processes -- Overview of popular diffusion MRI models -- Models applied to animal studies of neuroinflammation -- Models applied to human studies involving neuroinflammation -- Conclusion and outlook -- References -- Chapter 3: Iron imaging in neuroinflammation -- Introduction -- Iron and neuroinflammation -- Imaging iron in neuroinflammation -- Magnitude techniques and relaxation time measurements -- T2 -- T2* -- Phase-based iron imaging -- Susceptibility-weighted imaging (SWI) -- Susceptibility-based iron quantification -- Phase processing |
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Quantitative susceptibility mapping (QSM) -- Susceptibility source separation -- Miscellaneous considerations -- Iron oxide particles -- Field strength relevance -- Conclusions -- Acknowledgments -- References -- Chapter 4: MRS in neuroinflammation -- Abbreviations -- Introduction -- Brain metabolism accessible with MRS -- Metabolites visible with MRS -- NAA -- Creatine -- Choline -- Myo-inositol -- Lactate -- Glutamate and glutamine -- Glx -- Glutathione -- Gamma-aminobutyric acid -- GABA -- 2-Hydroxyglutarate (2HG) -- Macromolecules and lipids |
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Case study of MRS in neuroinflammation: Multiple sclerosis as a primary inflammatory disease -- Multiple sclerosis pathophysiology -- Metabolic changes measured by MRS in MS -- MRS data acquisition -- Basics of MRS data acquisition -- Signal localization -- Water suppression -- T1 nulling -- Chemical shift selective (CHESS) water suppression -- Variable power and optimized relaxations delays (VAPOR) -- Metabolite cycling (MC) -- Acquisition parameters -- Echo time -- Echo digitization -- Repetition time -- Voxel size and scan duration -- Spectral editing -- J-difference editing or editing -- Multinuclear MRS -- 31-Phosphorus -- 13-Carbon -- Diffusion MRS -- MRS data analysis -- Processing steps -- Processing -- Spectral fitting -- Peak modeling -- Linear combination modeling. |
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Tissue correction and metabolite quantification -- Water-referenced data -- Metabolite-referenced data -- Issues with metabolite quantification -- Spectral quality assurance and assessment -- Quality assurance during acquisition -- Artifacts -- Quality assessment and rejection thresholds -- Reporting standards and how to read MRS literature -- Summary -- References -- Further reading -- Chapter 5: Magnetization transfer and chemical exchange saturation transfer in neuroinflammation -- Abbreviations -- Introduction -- Central nervous system inflammation -- Magnetization transfer as an umbrella term -- MTC phenomenon and observations -- The MT experiment -- Quantification of the MT effect -- The MTR -- Quantitative MT (qMT) -- Origin of the MT effect -- MT imaging of acute inflammation: Histopathological and clinical validations -- MT imaging of chronic inflammation: Histopathological and clinical validations -- MT applications: Concluding remarks -- Chemical exchange saturation transfer -- Background -- CEST phenomenon and APT CEST -- The CEST experiment -- Quantification of CEST -- Confounds to the asymmetry measurement of the CEST effect -- Summary of confounds -- Model free CEST correction: AREX -- Model-based CEST correction: Lorentzian fitting -- CEST imaging of acute inflammation: Histopathological and clinical validations -- CEST imaging of chronic inflammation: Histopathological and clinical validations -- CEST applications: Concluding remarks -- Unmet needs and application opportunities -- Conclusion -- References -- Chapter 6: Gadolinium-based imaging of the blood brain barrier and brain waste clearance pathways -- Introduction -- Physiology and anatomy of the blood-brain barrier -- Paravascular and perivascular spaces -- Interstitial fluid -- Brain waste clearance pathways -- Glymphatic system. |
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Intramural periarterial drainage pathway-IPAD -- Meningeal lymphatics -- Gadolinium-based magnetic resonance imaging of brain waste clearance pathways and blood-brain barrier disruption -- Gadolinium-based contrast agents-Pharmacokinetics -- Gadolinium-based contrast agents-Signal intensity on MRI -- Intravenous injection of GBCA and in vivo MRI-based imaging -- Intrathecal injection of GBCA and in vivo MRI-based imaging -- Gadolinium-based MRI techniques and the disrupted blood-brain barrier -- Pathological conditions and clearance consequences of BBB disruption -- Conclusions -- References -- Chapter 7: Magnetic particle imaging -- In vivo cellular imaging with magnetic resonance imaging -- In vivo cellular imaging with magnetic particle imaging -- Basic principles of MPI -- Nanoparticles for MPI -- Analysis and quantification of MPI data -- MPI of inflammation -- MPI in the brain -- Challenges and limitations of MPI -- Future of MPI cell tracking -- References -- Chapter 8: Positron emission tomography imaging of neuroinflammation -- Abbreviations -- Introduction to neuroinflammation -- Biomarkers of neuroinflammation -- Microglia -- Neuroinflammatory imaging biomarkers present on the microglia -- Translocator protein (TSPO) -- Cannabinoid receptor type 2 (CB2R) -- P2X purinoceptor 7 (P2X7R) -- Colony-stimulating factor 1 receptor (CSF1R) -- Inducible nitric oxide synthase (iNOS) -- Oxidative stress -- Glycogen synthase kinase (GSK-3) -- Inflammatory cytokines -- Cyclooxygenase (COX) -- Infiltration of macrophages, neutrophils, and T-lymphocytes -- Interleukin-2 (IL-2) -- Matrix metalloproteinases 2 (MMP-2) -- Role of astrocytes -- Neuroinflammatory imaging biomarkers present on astrocytes -- Enzymes (MAOs) -- Reversible MAO-A/B binding inhibitor-based tracers -- Irreversible MAO-A/B binding inhibitors-based tracers -- Metabolite trapping approach. |
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Other emerging tracers -- Imidazoline-2 receptors (I2IR) -- Adenosine receptors -- Cytosolic phospholipase A2 (cPLA2) -- Conclusion -- Acknowledgment -- References -- Part 3: Animal models -- Chapter 9: The use of animal models of neuroinflammation for imaging studies -- Introduction -- Importance of preclinical models -- Applicability of preclinical models to humans -- Animal models of central nervous system neuroinflammation -- Transgenic mouse models -- Experimental autoimmune encephalomyelitis (EAE) -- Lipopolysaccharide (LPS) -- Cuprizone -- Stroke models -- Autism models -- Hypoxia -- Sex and hormone differences in animal models of CNS inflammation -- Gut microbiome-CNS axis -- Applicability and clinical relevance: Are there bad animal models of disease? -- Developing imaging methods to study CNS inflammation -- Gadolinium as a marker of neuroinflammation -- Inflammatory components for imaging consideration -- Imaging physiological, microstructural, and biochemical changes -- New horizons -- Acknowledgments -- References -- Part 4: Human inflammation-based diseases -- Chapter 10: Stroke -- Introduction -- Stroke pathophysiology -- Neuroinflammation in stroke -- Microglia -- Adhesion molecules and leukocytes -- Inflammation resolution -- The influence of systemic and neuroinflammation on stroke recovery -- Dynamic contrast enhanced imaging -- Diffusion imaging -- Magnetic resonance spectroscopy -- Positron emission tomography -- Superparamagnetic particles of iron oxide enhanced MRI -- Conclusion -- References -- Chapter 11: Central nervous system vasculitis -- Historical diagnostic approach -- Cerebrospinal fluid -- Neuroimaging -- Biopsy -- Vessel wall magnetic resonance imaging (VWMRI) -- Diagnostic features -- Technical considerations and imaging pitfalls -- Differential diagnosis -- Reversible cerebral vasoconstriction syndrome (RCVS) -- Intracranial atherosclerosis. |
| Summary |
"Imaging Neuroinflammation provides an overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy, reviews state-of-the-art imaging tools available to measure neuroinflammation, and describes the application of those tools to both preclinical animal disease models and human disease.This book is an authoritative reference on imaging neuroinflammation, MRI, neuroinflammation, MR Spectroscopy of inflammation, Iron imaging in inflammation, and more. Explains how inflammation in the central nervous system impacts tissue microstructure. Presents imaging methods that are useful for assessing neuroinflammation. Describes preclinical models of neuroinflammation. Reviews the role of neuroinflammation in human injury and disease states"--Publisher. |
| Note |
Description based on print version record. |
| Subject |
Central nervous system -- Imaging.
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Inflammation.
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Magnetic resonance imaging.
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Neuroinflammatory Diseases -- diagnostic imaging |
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Inflammation |
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Magnetic Resonance Imaging |
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Système nerveux central -- Imagerie.
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Inflammation (Pathologie)
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Imagerie par résonance magnétique.
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| Added Author |
Laule, Cornelia, editor.
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Port, John, editor.
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| Other Form: |
Print version : 9780323917711 |
| ISBN |
9780323972246 ePub ebook |
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0323972241 ePub ebook |
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0323917712 paperback |
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9780323917711 paperback |
| Standard No. |
AU@ 000075245679 |
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UKMGB 020952118 |
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AU@ 000074384521 |
