| Description |
1 online resource |
| Series |
Drug Discovery Update Series |
|
Drug Discovery Update Series.
|
| Contents |
Front Cover -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- Copyright -- Contents -- Contributors -- I -- Biochemical and molecular aspects -- 1 -- Structures and functions of biomolecules -- 1. Introduction -- 1.1 About biomolecules -- 1.2 Carbohydrates -- 1.2.1 Structure of carbohydrates -- 1.2.2 Functions of carbohydrates -- 1.3 Proteins -- 1.3.1 Structure of proteins -- 1.3.2 Functions of proteins -- 1.4 Lipids -- 1.4.1 Structure of lipids -- 1.4.2 Functions of lipids -- 1.5 Nucleic acids |
|
1.5.1 Structure of nucleic acids -- 1.5.1.1 Types of RNA -- 1.5.2 Functions of nucleic acids -- 2. Structure Activity Relationship (SAR) -- 2.1 Need for the SAR study -- 3. Ligands -- 3.1 Classification of ligands -- 4. Receptors -- 4.1 Classification of receptors -- 4.2 Some of the examples of the receptors acting as therapeutic targets -- 5. Conclusion -- References -- 2 -- Pharmacokinetics and pharmacodynamics -- 1. Introduction -- 1.1 Sources of drugs -- 1.2 Drug nomenclature -- 1.3 Drug classification -- 1.4 Drug transport through cell membranes -- 1.4.1 Simple diffusion -- 1.4.2 Filtration |
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1.4.3 Carrier mediated -- 1.4.4 Endocytosis -- 2. Pharmacokinetics (ADME) -- 2.1 Absorption -- 2.1.1 Bioavailability -- 2.1.1.1 Factors affecting oral bioavailability -- 2.1.2 Factors influencing digestive resorption -- 2.1.2.1 Pharmaceutical form -- 2.1.2.2 pH, PKa, log P, molecular weight -- 2.1.2.3 Metabolism in the digestive tract, gastric secretion and food bowl -- 2.1.2.4 First pass effect -- 2.1.2.5 Other factors -- 2.2 Distribution -- 2.2.1 Patterns of distribution -- 2.2.2 Factors affecting distribution of drugs -- 2.2.3 Apparent volume of distribution (Vd) |
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2.3 Metabolism (biotransformation) -- 2.3.1 Site of metabolism -- 2.3.2 Types of metabolic reactions -- 2.3.3 Enzymes responsible for biotransformation -- 2.3.4 Factors affecting hepatic microsomal enzyme activity -- 2.4 Excretion -- 2.4.1 Clearance -- 2.5 Fundamental principles of pharmacokinetics -- 2.5.1 Plasma half-life (t1/2) -- 2.5.2 Loading dose -- 2.5.3 Maintenance dose -- 2.5.4 Methods used to prolong duration of action of drugs -- 3. Pharmacodynamics -- 3.1 Possible mechanisms of action of drugs -- 3.2 Definition of receptors -- 3.3 Affinity -- 3.4 Efficacy -- 3.5 Potency |
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3.6 The amount of response -- 3.7 Relation between concentration and response -- 3.7.1 Dose-response curve of drugs -- 3.7.2 Types of ligands -- 3.7.3 Types of antagonists -- 3.7.4 Non-competitive block types -- 3.7.5 Types of receptors and signal transduction mechanism -- 4. Conclusion -- References -- 3 -- Overview of drugs and drug targets -- 1. Introduction -- 1.1 Drug development process -- 1.2 Discovery -- 1.2.1 Target identification and validation -- 1.2.2 Assay development -- 1.2.3 Lead identification -- 1.2.4 Lead optimization -- 1.3 Development -- 1.3.1 Predevelopment |
| Subject |
Pharmacology.
|
|
Molecular pharmacology.
|
|
Pharmacology |
|
Pharmacologie.
|
|
Pharmacologie moléculaire.
|
|
pharmacology.
|
| Other Form: |
Original 0443160139 9780443160134 (OCoLC)1390915323 |
| ISBN |
9780443160141 (electronic bk.) |
|
0443160147 (electronic bk.) |
|
9780443160134 |
|
0443160139 |
| Standard No. |
AU@ 000077312309 |
|
AU@ 000077343302 |
|
