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Title Applications of toxicogenomics in safety evaluation and risk assessment / edited by Darrell R. Boverhof, B. Bhaskar Gollapudi.

Imprint Hoboken, N.J. : John Wiley & Sons, ©2011.

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Location Call No. OPAC Message Status
 Axe EBSCO Clinical Nursing E-Book  Electronic Book    ---  Available
Description 1 online resource (xiii, 377 pages) : illustrations
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
data file rda
Bibliography Includes bibliographical references and index.
Contents Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach.
Summary "This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher.
Note Print version record.
Language English.
Subject Genetic toxicology.
Toxicity testing.
Health risk assessment.
Risk assessment.
Toxicogenetics
Risk Assessment
Health Status Indicators
Toxicologie génétique.
Risques pour la santé -- Évaluation.
Évaluation du risque.
risk assessment.
HEALTH & FITNESS -- Diseases -- Genetic.
MEDICAL -- Genetics.
Risk assessment. (OCoLC)fst01098146
Genetic toxicology. (OCoLC)fst00940097
Health risk assessment. (OCoLC)fst00953250
Toxicity testing. (OCoLC)fst01153336
Public Health.
Health & Biological Sciences.
Toxicology & Public Health.
Genre/Form Electronic books.
Electronic books.
Electronic resource.
Added Author Boverhof, Darrell R.
Gollapudi, B. Bhaskar.
Other Form: Print version: Applications of toxicogenomics in safety evaluation and risk assessment. Hoboken, N.J. : John Wiley & Sons, ©2011 9780470449820 (DLC) 2010043286 (OCoLC)671385938
ISBN 9781118001042 (electronic bk.)
1118001044 (electronic bk.)
9781118001035 (electronic bk.)
1118001036 (electronic bk.)
9781118008980 (electronic bk.)
1118008987 (electronic bk.)
9780470449820 (cloth)
0470449829 (cloth)
1283239663
9781283239660
9786613239662
6613239666
Standard No. AU@ 000047980892
AU@ 000051555658
AU@ 000060546891
CHNEW 000938023
CHVBK 480183309
DEBBG BV043095691
DEBBG BV043393349
DEBBG BV044154369
DEBSZ 421535199
DEBSZ 430989636
DEBSZ 485004712
HEBIS 299830756
NZ1 14256978

 
    
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