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Title Bicuspid aortic valve : diagnosis, surgical treatment and complications / Anthony Chapman, editor.

Publication Info. New York : Nova Biomedical, 2015.
2015

Copies

Location Call No. OPAC Message Status
 Axe EBSCO Clinical Nursing E-Book  Electronic Book    ---  Available
Description 1 online resource (x, 90 pages) : illustrations
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Congenital disorders - laboratory and clinical research
Congenital disorders: laboratory and clinical research series.
Note Online resource; title from PDF title page (EBSCO, viewed August 12, 2015).
Bibliography Includes bibliographical references and index.
Contents BICUSPID AORTIC VALVE: DIAGNOSIS, SURGICAL TREATMENT AND COMPLICATIONS -- BICUSPID AORTIC VALVE: DIAGNOSIS, SURGICAL TREATMENT AND COMPLICATIONS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter 1: Bicuspid Aortic Valve Syndrome: From the Etiology to the Surgical Strategies of Treatment -- Abstract -- Definition and Epidemiology of Aortic Pathology -- Etiopathogenesis of the Aortic Disease -- Histology of the Aortic Wall -- Anatomic Classification and Natural History -- Diagnosis -- Surgical Treatment -- Discussion -- References -- Chapter 2: Genetic Influences on Phenotype in Bicuspid Aortic Valve: Screening, Diagnosis and Prognosis -- Abstract -- Introduction -- Evidence for Heritability of BAV -- Normal Valve Development -- Animal Models of BAV -- Human Genetic Syndromes -- Linkage Analyses -- Target Gene Approach -- Next Generation Sequencing -- Genome-Wide Association Studies (GWAS) -- Genetic Basis of Thoracic Aortic Aneurysm (TAA) in BAV -- Thoracic Aortic Aneurysm Associated with BAV: Haemodynamic Theory -- Genotype-Phenotype Correlations -- Phenotype Modifiers -- Common Variants -- microRNAs: The New Kids on the Block -- State of Knowledge -- Conclusion -- Chapter 3: Genetic Basis, Pathogenesis and Histopathology of Aortopathy in Bicuspid Aortic Valve and Marfan syndrome -- Abstract -- Frequency and Possible Causes of Aortic Dilation (Aneurysms) -- Discussion -- Conclusion and Future Directions -- Acknowledgments -- References -- Index -- Blank Page.
Summary Bicuspid aortic valve (BAV) is the most common congenital pathology of the aortic valve occurring in 0.5-2% of the general population and frequently requiring surgical management after the fourth decade of life. From the etiology to the surgical management of BAV is analyzed. Other chapters review genome-wide association studies, linkage analyses and next-generation sequencing studies, which are beginning to build a more comprehensive picture of the genetic bases of BAV. The prospects for developing tools for genetic screening of families and for risk stratification are explored as well, including the future steps which are necessary for the creation of an individualized approach to managing BAV. The last chapter is a review of the present understanding of ascending thoracic aortic aneurysm pathogenesis. The genetic basis and basic pathology underlying BAV and ascending thoracic aortic aneurysms are discussed as well, and are compared to known mechanisms underlying other aortopathologies.
Subject Aortic valve -- Stenosis -- Surgery.
Heart valve prosthesis.
Cardiac catheterization.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Cardiac catheterization. (OCoLC)fst00847050
Heart valve prosthesis. (OCoLC)fst00953745
Genre/Form Electronic books.
Added Author Chapman, Anthony (Editor), editor.
ISBN 9781634828093 (electronic bk.)
1634828097 (electronic bk.)
9781634827867
Standard No. AU@ 000056951361

 
    
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