| Description |
1 online resource (xii, 314 pages) |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Note |
Vendor-supplied metadata. |
| Bibliography |
Includes bibliographical references and index. |
| Summary |
The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. |
| Contents |
Front Cover; Anti-Angiogenesis Drug Discovery and Development Volume 2 ; Copyright ; Contents ; Preface ; List of Contributors ; Chapter 1: Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis ; Abstract ; Introduction ; An Historical Overview of Angiogenesis ; Types of Angiogenesis ; The Mechanism of Normal Angiogenesis ; Tumor Indduced Anngiogeneesis ; Assays for Angiogenesis ; Mechanism of Angiogenesis Inhibition ; Inhibitors of Growth Factors and Receptors ; An Overview of Anti-Angiogenic Therapy ; Conclusion. |
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Acknowledgements Conflict of Interest ; References ; Chapter 2: Development of in vitro Method for Assaying Anti-Angiogenic Effect of Drugs ; Abstract ; Introduction ; Collagenn Gel Cullture of Aortic Eexplant ; Capillary Tube Formation ; Immunohistochemistry of Angiogenic Factors ; Adhesive Molecules (integrins) ; CD133 (Hematopoietic Stem/Progenitor Cell Marker ; Gene Array Analysis ; Anti-Angiogenic Drugs ; Collagen Gel Culture as an in vitro Model for Studyingvascular Injury ; Collagen Gel Culture of Various Organs ; Conclusion ; Acknowledgements ; Conflict of Interest ; Disclosures. |
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Cconclusion Acknowledgements ; Conflict of Interest ; Disclosure ; References ; Chapter 5: Development of Novel Anti-Cancer Strategies Based Onangiogenesis Inhibition ; Abstract ; Introduction ; Physiological Angiogenesis ; Pathological Angiogenesis ; Factors Responsible for Angiogenesis ; Molecules Involved in Angiogenesis ; Signal Transduction Pathways Involved in Angiogenesis ; Strategies for Targeting Angiogenesis ; Naturally Occurring Inhibitors ; Mimics for Angiogenesis ; Synthetic Inhibitors ; Concluding Remarks ; Acknowledgements ; Conflict of Interest ; References. |
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Chapter 6: Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer Abstract ; Introduction ; Mechanisms of Action ; Resistance ; General Toxicities ; Agents Bevacizumab ; Aflibercept (VEGF Trap) ; BIBF1120 ; Additional Antiangiogenics ; MEDI3617 ; Novel Delivery of Antiangiogenics ; Limitations and Future Clinical Use ; Registration Strategies ; Combination Antivascular Therapies ; Conclusion ; Acknowledgements ; Conflict of Interest ; Competing Interests ; References ; Chapter 7: STAT3 Signaling in Cancer: Small Molecule Intervention as Therapy? ; Abstract. |
| Subject |
Neovascularization inhibitors.
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Angiogenesis Modulating Agents |
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Angiogenesis Inhibitors |
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Néovascularisation -- Inhibiteurs.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Neovascularization inhibitors
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| Genre/Form |
Internet Resources.
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| Added Author |
Rahman, Atta-ur-, 1942- editor.
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Choudhary, Muhammad Iqbal, editor.
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| ISBN |
9780128039649 (electronic bk.) |
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0128039647 (electronic bk.) |
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9780128039632 (electronic bk.) |
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0128039639 (electronic bk.) |
| Standard No. |
AU@ 000054991972 |
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CHBIS 010547976 |
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CHVBK 341784109 |
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DEBBG BV043216417 |
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DEBSZ 45152716X |
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DEBSZ 482375426 |
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