| Description |
1 online resource (xv, 444 pages) : illustrations (some color) |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Contributing Authors; Introduction Karl Peter Giese; Chapter 1: Long-term Potentiation and Memory Karl Peter Giese; 1. Introduction; 2. Key properties of LTP; 3. Training-induced occurrence of LTP; 4. LTP and Hebb's postulate; 5. Molecular mechanisms underlying LTP; 6. Is LTP required for memory?; 7. A specific role for CA1 LTP; 8. LTP and long-term memory storage; 9. LTP and sex differences; 10. Conclusion; References; Chapter 2: Structural Synaptic and Dendritic Spine Plasticity in the Hippocampus Michael G. Stewart, and Victor I. Popov; 1. Introduction. |
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2. Methods to study structural synaptic and dendritic plasticity3. Structural plasticity of spines; 4. Synaptic plasticity, LTP, and learning; 5. What is the structural basis for synaptic plasticity?; 6. Learning-related structural changes; 7. Pre- or postsynaptic location of structural plasticity changes?; 8. Time scale over which structural changes occur; Short-term structural changes; Synaptic vesicles; Long-term structural changes; 9. Synapse pruning -- Masking of plasticity; 10. Spinules at the PSD; 11. What are the cellular processes involved in spine and synapse remodelling? |
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Dendritic spinesSynaptic boutons; 12. Neural cell adhesion molecule (NCAM); Synaptic apposition zone curvature changes; 13. Alterations in synaptic and dendritic organelles; Endosomes; 14. Is structural synapse and spine plasticity durable?; 15. Conclusion; References; Chapter 3: Memory Beyond Synaptic Plasticity: The Role of Intrinsic Neuronal Excitability Athanasia Papoutsi, Kyriaki Sidiropoulou and Panayiota Poirazi; 1. Introduction; 2. General aspects of plasticity of intrinsic neuronal excitability; 2.1. Biophysical and morphological properties shape intrinsic excitability. |
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2.2. Plasticity of intrinsic excitability depends on ionic mechanisms3. Learning and experience-dependent plasticity of neuronal excitability; 4. Activity-dependent plasticity of intrinsic excitability; 4.1. The E-S coupling phenomenon; 4.1.1. Activity-dependent changes in intrinsic mechanisms located at the soma; 4.1.2. Activity-dependent changes in dendritic ion channels; 4.2. Homeostatic plasticity; 5. Interaction between intrinsic and synaptic plasticity; 6. Contribution of plasticity of excitability in short-term memory. |
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6.1. Interplay of plasticity of excitability and short-term synaptic plasticity6.2. Plasticity of excitability and working memory; 7. Conclusion; Acknowledgments; References; Chapter 4: Adult Hippocampal Neurogenesis and Memory Scellig S.D. Stone and Paul W. Frankland; 1. Introduction; 2. Biology of adult hippocampal neurogenesis; 2.1. Anatomy of the dentate gyrus; 2.2. Identification and quantification of neurogenesis; 2.3. Adult-generated DGC development; 2.3.1. Technical considerations; 2.3.2. Stem and progenitor origins; 2.3.3. Morphological development. |
| Summary |
Memory Mechanisms is an edited review volume that summarizes state-of-the-art knowledge on memory mechanisms at the molecular, cellular and circuit level. Each review is written by leading experts in the field, presenting not only current knowledge, but also discussing the concepts, providing critical reflections and suggesting an outlook for future studies. The memory mechanisms are also discussed in the context of diseases. Studies of memory deficits in disease models are introduced as well as approaches to restore memory deficits. Finally, the impact of contemporary memory research for psyc. |
| Subject |
Memory.
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Brain -- Diseases.
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Memory -- physiology |
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Brain -- physiology |
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Long-Term Potentiation -- physiology |
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Nervous System Physiological Phenomena |
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Brain Diseases |
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Medicine.
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Cerveau -- Maladies.
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HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
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MEDICAL -- Neurology.
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Brain -- Diseases
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Memory
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| Added Author |
Giese, Karl Peter.
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| Other Form: |
Print version: Giese, Karl Peter. Memory Mechanisms in Health and Disease : Mechanistic Basis of Memory. Singapore : World Scientific, ©2012 9789814366694 |
| ISBN |
9789814366700 (electronic bk.) |
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9814366706 (electronic bk.) |
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1281603589 |
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9781281603586 |
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9814366692 |
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9789814366694 |
| Standard No. |
DEBBG BV043059487 |
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DEBSZ 446488429 |
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NZ1 14694063 |
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