HUNTINGTON'S DISEASE ; Library of Congress Cataloging-in-Publication Data ; Contents ; Preface ; Chapter I Huntington's Disease: From Disease Pathogenesisto Clinical Perspectives ; Abstract ; Clinical Features of Huntington's Disease ; Huntingtin's Structure and Post-Translational Modifications ; Htt Function; Molecular Mechanisms of HD Pathogenesis ; Clinical Perspectives in HD ; Conclusion ; Acknowledgments ; Conflict of Interest ; References ; Chapter II The Role of Brain-Derived Neurotrophic Factor (BDNF)in Huntington's Disease: Trophic Support as a Therapeutic Strategy ; Abstract.
Abbreviations 1. Huntington's Disease ; 2. Brain-Derived Neurotrophic Factor (BDNF) ; 2.1. Neurotrophins ; 2.2. Neurotrophin Receptors and their Normal Functions ; 3. Wild-Type versus Mutant Huntingtin and BDNF ; 3.1. Regulation of BDNF Transcription by Huntingtin ; 3.2. Regulation of BDNF Transport by Huntingtin ; 4. Evidence for Reduced Trophic Support in the HD Brain ; 4.1. Reduction in BDNF Expression in HD Genetic Mouse Models ; 4.2. Reduction in BDNF Expression in the Human HD Brain ; 5. Increasing Trophic Support as a Therapeutic Intervention for HD.
5.1. Direct Up-Regulation of Striatal BDNF Levels 5.2. Up-Regulation of BDNF Levels by Pharmacological Strategies ; 5.3. Up-Regulation of BDNF Levels by Non-Invasive Strategies; 5.4. Future Directions ; Conclusion ; Acknowledgments ; References ; Chapter III The Legal Ramifications ofHuntington's Disease ; Author's Note ; Abstract ; Introduction ; Clinical Issues Relevant to the Law ; HD and Insurance ; Imposition of Involuntary Status ; Guardianship Hearings ; Family Law ; Criminal Law ; Probate ; Compensation ; Conclusion ; References ; Index.
