| Description |
vii, 288 p. : ill. ; 24 cm. |
| Series |
NIDA research monograph ; 134
|
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NIH publication ; no. 93-3638
|
| Note |
S/N 017-024-01511-3 (GPO) |
|
"Based on the papers and discussions from a technical review on ... held on November 14-16, 1991"--T.p. verso. |
| Bibliography |
Includes bibliographical references. |
| Contents |
Strategies for drug discovery / Michael Williams -- Mass ligand-binding screening strategies for identification of leads for new drug discovery / Ronald M. Burch -- Antibody- and peptide structure-based drug design / Manfred E. Wolff -- The use of cloned human receptors for drug design / Paul R. Hartig -- Synthetic peptide combinatorial libraries may be used to determine peptide ligands for opioid receptors / Richard A. Houghten and Colette T. Dooley -- Preparation of large peptide libraries with one peptide per bead and their use for the discovery of peptides that bind to acceptors / Victor J. Hruby ... [et al.] -- Computer design of bioactive compounds based on 3-D properties of ligands / Y.C. Martin -- Toward the design of new inhibitors : a computer modeling approach / Carlos H. Faerman -- Efforts to improve the utilization of protein sequence and structure databases / Nagarajan Pattabiraman and Krishnan Namboodiri -- Use of computer graphics in drug design / G.W.A. Milne and M.C. Nicklaus -- Purification and cloning of opioid receptors / Ling-Yuan Li ... [et al.] -- Computer-assisted design of dopamine transporter ligands / Gilda H. Loew ... [et al.] -- The pharmacophore for opioid activity / Mark Froimowitz -- The molecular basis of opioid potency and selectivity : morphiceptins, dermorphins, deltorphins, and enkephalins / Murray Goodman ... [et al.] -- Molecular determinants of cannabinoid activity : toward the design of cannabinoid analgesics with reduced psychoactive liability / Patricia H. Reggio -- Cocaine receptor : a structure-activity relationship study / F. Ivy Carroll ... [et al.] -- The use of conformational restriction and molecular modeling techniques in the development of receptor-specific opioid peptide agonists and antagonists / Peter W. Schiller ... [et al.] -- Probes for the cannabinoid sites of action / Alexandros Makriyannis -- A model for the structural basis of [delta]b2s-opioid receptor selectivity / Henry I. Mosberg and Frank Porreca. |
| Subject |
Drugs -- Design -- Data processing.
|
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Computer-aided design.
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Automatic Data Processing -- Congresses. |
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Drug Design -- Congresses. |
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Drug Utilization -- Congresses. |
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Substance Abuse -- Congresses. |
| Added Author |
Rapaka, Rao S.
|
|
Hawks, Richard L.
|
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National Institute on Drug Abuse.
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| Added Title |
Drug discovery, databases, and computer-aided drug design.
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| ISBN |
0160424771 : $11.00 |
| Gpo Item No. |
0813-C-08 |
| Sudoc No. |
HE 20.8216:134 |
|
