| Description |
1 online resource (xiv, 346 pages) : illustrations |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Data handling in science and technology ; v. 19 |
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Data handling in science and technology ; v. 19.
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| Bibliography |
Includes bibliographical references and index. |
| Contents |
General introduction to robustness / Age K. Smilde -- Stability and response surface methodology / Stephen P. Jones -- Review of the use of robustness and ruggedness in analytical chemistry / Y. Vander Heyden, D.L. Massart -- Robustness criteria. Incorporating robustness explicitly in optimization procedures utilizing multicriteria methods / Jan H. de Boer -- Ruggedness tests for analytical chemistry / Mary Mulholland -- Stabilizing a TLC separation illustrated by a mixture of several street drugs / C.A.A. Duineveld, P. Koopmans, P.M.J. Coenegracht -- Robustness of liquid-liquid extraction of drugs from biological samples / Jacob Wieling -- The use of a factorial design to evaluate the physical stability of tablets after storage under tropical conditions / C.E. Bos, G.K. Bolhuis, A.K. Smilde, J.H. de Boer. |
| Summary |
In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given. Features of this book: & bull; Gives a good overview of mathematical and statistical methods used in two application areas, i.e. pharmaceutical technology and analytical chemistry & bull; Illustrates the different approaches available to attain robustness & bull; Gives ideas on how to use methods in practical situations. The book is intended for those who develop and optimize, and are responsible for the overall quality of, analytical methods and pharmaceutical technological products and procedures. |
| Note |
Print version record. |
| Subject |
Drugs -- Analysis -- Statistical methods.
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Chemometrics.
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Robust statistics.
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Pharmaceutical technology -- Statistical methods.
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Drugs -- Design.
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Quality control.
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Drug Design |
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Pharmaceutical Preparations -- analysis |
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Data Interpretation, Statistical |
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Drug Compounding |
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Quality Control |
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Médicaments -- Analyse -- Méthodes statistiques.
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Chimiométrie.
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Statistiques robustes.
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Techniques pharmaceutiques -- Méthodes statistiques.
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Médicaments -- Conception.
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Qualité -- Contrôle.
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quality control.
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MEDICAL -- Drug Guides.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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MEDICAL -- Nursing -- Pharmacology.
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Quality control
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Drugs -- Design
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Chemometrics
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Drugs -- Analysis -- Statistical methods
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Robust statistics
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| Added Author |
Hendricks, Margriet M. W. B.
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Boer, Jan H. de, 1963-
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Smilde, Age K.
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| Other Form: |
Print version: Robustness of analytical chemical methods and pharmaceutical technological products. Amsterdam ; New York : Elsevier, ©1996 0444897097 9780444897091 (DLC) 96046758 (OCoLC)36037871 |
| ISBN |
9780444897091 |
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0444897097 |
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9780080540634 (electronic bk.) |
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0080540635 (electronic bk.) |
| Standard No. |
AU@ 000054979219 |
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DEBBG BV039828602 |
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DEBBG BV042313828 |
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DEBSZ 367768399 |
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DEBSZ 48235254X |
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NZ1 12432868 |
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NZ1 15188822 |
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NZ1 16061366 |
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