| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Bibliography |
Includes bibliographical references and index. |
| Summary |
Non-alcoholic fatty liver disease (NAFLD) is a common cause of elevated liver enzymes and chronic liver disease in Western countries. NAFLD is characterized by elevated liver enzymes in the absence of alcohol consumption and secondary causes of liver disease. It is an independent predictor of future risk of cardiovascular diseases, type 2 diabetes and metabolic syndrome (hypertension, abdominal obesity, dyslipidemia, glucose intolerance). This book is a quick reference guide for medical students and professionals about NAFLD. Readers will find a summary of epidemiology, clinical features, diagnosis, imaging techniques, histopathology, and disease management. The book also presents information about NAFLD linked with hepatocellular carcinoma and guidelines for treating NAFLD in pediatric patients. Each chapter presents information in a simple, structured manner making this text an ideal handbook for supplementing hepatology modules in medical curricula. |
| Note |
Print version record. |
| Contents |
Intro -- CONTENTS -- FOREWORD -- PREFACE -- List of Contributors -- Epidemiology of NAFLD -- Alajos Par* -- INTRODUCTION -- PREVALENCE OF NAFLD AND NASH -- Liver Biopsy and Autopsy Studies -- Ultrasound (US) -- Magnetic Resonance Imaging (MRI) -- Non-invasive Biomarker for Fibrosis: Fibrotest -- Elevation in Liver Enzymes and Combinations of Clinical Variables -- RISK FACTORS -- Age -- Gender -- Race, Ethnicity and Gene Variants -- Metabolic Disorders -- Polycystic Ovarian Syndrome (PCOS) -- Hepatitis C Virus (HCV) -- NATURAL HISTORY -- BRIEFLY ON NAFLD AND CARDIOVASCULAR DISEASE (CVD) -- SUMMARY -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Clinical Manifestations and Diagnosis of NAFLD -- István Tornai* -- INTRODUCTION -- Extrahepatic Complications of NAFLD -- Cardiovascular Disorders and NAFLD -- Chronic Kidney Disease and NAFLD -- Osteoporosis and NAFLD -- Endocrinopathies -- Hypothyroidism -- Polycystic Ovarian Syndrome -- Obstructive Sleep Apnea Syndrome -- Carcinogenesis and NAFLD -- Colorectal Cancer -- Progression of Liver Disease in NAFLD -- Patients with Risk of Progression -- Cirrhotic NASH -- Alcohol and NAFLD -- NASH in Lean Patients -- Diagnosis of NAFLD -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Imaging of NAFLD -- Zoltán Harmat* and Omar Giyab -- INTRODUCTION -- IMAGING MODALITIES -- Ultrasound -- Sonoelastography -- Computed Tomography -- Magnetic Resonance Imaging -- Chemical Shift Imaging -- Fast SE Imaging -- MR Spectroscopy -- MR Elastography -- CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Histopathological Changes of NAFLD -- Peter Nagy* -- INTRODUCTION -- GENERAL HISTOLOGICAL FEATURES OF NAFLD -- THE ROLE AND VALUE OF LIVER BIOPSY IN THE DIAGNOSIS AND TREATMENT OF NAFLD PATIENTS -- HISTOLOGICAL CHARACTERISTICS OF NAFLD -- Steatosis -- Inflammation. |
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Hepatocellular Injury, Ballooning -- Liver Fibrosis and Ductular Reaction -- NAFLD-RELATED CIRRHOSIS -- NAFLD AND HEPATOCELLULAR CARCINOMA -- PEDIATRIC NAFLD -- HISTOLOGICAL SCORING OF NAFLD -- DIFFERENTIAL DIAGNOSTIC CONSIDERATIONS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Pathophysiology of NAFLD -- Gabriella Par* -- INTRODUCTION -- EXTRAHEPATIC AND INTRAHEPATIC MECHANISMS IN NAFLD -- Extrahepatic Mechanisms -- Intrahepatic Mechanisms -- Enzymes -- Transcription Factors -- GENETICS AND EPIGENETIC EFFECTS -- Genetics -- Epigenetic Effects -- ADIPOKINES -- OXIDATIVE AND ENDOPLASMIC RETICULUM STRESS -- INSULIN RESISTANCE (IR) -- OBESITY -- APOPTOSIS -- HEPATOCYTE SENESCENCE -- IMMUNE RESPONSE -- Toll-like Receptors -- Th17 Response -- FIBROSIS, HEPATOCYTE BALLOONING, HEDGEHOG PATHWAY AND VITAMIN E IN NASH -- Hepatocyte Ballooning -- Hedgehog Pathway -- Vitamin E -- SUMMARY -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Metabolic Diseases and NAFLD -- Tatjana Ábela,b,* -- INTRODUCTION -- OBESITY -- TYPE 2 DIABETES -- LIPID DISORDERS -- HYPERTENSION -- METABOLIC SYNDROME -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Management of NAFLD -- Krisztina Hagymási* and Gabriella Lengyel -- INTRODUCTION -- Treatment -- Reduction of Body Weight -- Diet -- Physical Activity -- Pharmacotherapy -- Improving Insulin Sensitivity -- Reduction of Lipid Levels -- Antioxidants -- Ursodeoxycholic Acid -- Liver Transplantation -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma -- György Baffy* -- INTRODUCTION -- RISK FACTORS OF HCC IN NAFLD -- Obesity and Diabetes -- NAFLD with Advanced Fibrosis -- NAFLD without Advanced Fibrosis -- Concurrent Chronic Liver Disease. |
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MOLECULAR MECHANISMS OF HCC DEVELOPMENT IN NAFLD -- Oncogenic Pathways in Cirrhosis -- Genetic Variability and Predisposition to NAFLD-HCC -- Adipose Expansion and Adipokine Imbalance -- Lipotoxicity -- Insulin Resistance -- Altered Gut Microbiota -- MicroRNAs and Hepatocarcinogenesis -- DIAGNOSIS OF NAFLD-HCC -- Clinical Presentation -- Biomarkers of HCC Development in NAFLD -- RISK REDUCTION STRATEGIES FOR HCC COMPLICATING NAFLD -- Screening and Surveillance -- Lifestyle Measures -- Insulin-sensitizing Agents -- Emerging Opportunities for Chemoprevention -- PERSPECTIVES -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Non-Alcoholic Fatty Liver Disease in the Pediatric Population -- Zsuzsanna Almássy* -- INTRODUCTION -- EPIDEMIOLOGY, PATHOGENESIS -- NAFLD AND CVD IN CHILDREN -- RISK AND DEVELOPMENT OF NAFLD -- DEVELOPMENT OF NAFLD -- DIAGNOSIS AND PROGNOSIS -- THERAPY AND FOLLOW-UP OF PATIENTS -- CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- SUBJECT INDEX. |
| Subject |
Fatty liver.
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Liver -- Diseases.
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Fatty Liver |
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Stéatose hépatique.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Fatty liver
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Liver -- Diseases
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| Added Author |
Ábel, Tatjana, editor.
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Lengyel, Gabriella, editor.
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| Other Form: |
Print version: Ábel, Tatjana. Nonalcoholic Fatty Liver Disease (NAFLD). Sharjah : Bentham Science Publishers, ©2017 9781681084602 |
| ISBN |
9781681084657 (electronic bk.) |
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1681084651 (electronic bk.) |
| Standard No. |
AU@ 000061011140 |
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AU@ 000068464208 |
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