| Description |
1 online resource (xiv, 371 pages) : color illustrations |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
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text file |
| Note |
Online resource; title from PDF title page (EBSCO, viewed May 5, 2016). |
| Bibliography |
Includes bibliographical references and indexes. |
| Summary |
Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-friendly methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency. The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitive organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area. Features cutting-edge research in the field of mechanochemical organic synthesis for more sustainable reactionsIntegrates advances in green chemistry research into industrial applications and process development. Focuses on designing techniques in organic synthesis directed toward mild reaction conditionsIncludes global coverage of mechanochemical synthetic protocols for the generation of organic compounds |
| Contents |
Front Cover; Mechanochemical Organic Synthesis; Mechanochemical Organic Synthesis; Copyright; Contents; Preface; List of Abbreviations; 1 -- Practical Considerations in Mechanochemical Organic Synthesis; 1.1 A HISTORICAL PERSPECTIVE; 1.2 MODERN LABORATORY INSTRUMENTATION FOR MECHANOSYNTHESIS; 1.2.1 PLANETARY BALL MILLS; 1.2.2 MIXER (SHAKER) BALL MILLS; 1.2.3 CUSTOM-MADE BALL MILLS; 1.2.4 MILLING PARAMETERS; 1.3 CONTAMINATION FROM WEAR IN ORGANIC MECHANOSYNTHESIS; 1.4 ANALYSIS AND MONITORING OF MECHANOCHEMICAL REACTIONS; 1.4.1 ANALYTICAL METHODS IN ORGANIC SOLID-STATE CHEMISTRY |
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1.4.2 MONITORING OF MECHANOCHEMICAL REACTIONS1.4.2.1 Ex Situ Monitoring; 1.4.2.2 In Situ Monitoring; REFERENCES; 2 -- Carbon-Carbon Bond- Forming Reactions; 2.1 HECK COUPLING; 2.2 SUZUKI COUPLING; 2.3 SONOGASHIRA COUPLING; 2.4 GLASER COUPLING; 2.5 MICHAEL REACTION; 2.5.1 ASYMMETRIC MICHAEL REACTION; 2.6 ALDOL CONDENSATION; 2.6.1 ASYMMETRIC ALDOL CONDENSATION; 2.7 MORITA-BAYLIS-HILLMAN REACTION; 2.8 KNOEVENAGEL CONDENSATION; 2.9 BARBIER ALLYLATION; 2.10 GEWALD REACTION; 2.11 PINACOL REACTION; 2.12 GRIGNARD AND MCMURRY REACTIONS; 2.13 GRIGNARD-ZEREWITINOFF-LIKE REACTION; 2.14 WITTIG REACTION |
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2.15 HORNER-WADSWORTH-EMMONS REACTION2.16 ASYMMETRIC ALKYLATION; 2.17 OLEFIN CROSS-METATHESIS; 2.18 CROSS-DEHYDROGENATIVE COUPLING; 2.19 REFORMATSKY REACTION; 2.20 CASCADE REACTIONS; 2.20.1 PORPHYRIN SYNTHESIS; 2.20.2 NINHYDRIN CONDENSATIONS; 2.21 ARYLAMINOMETHYLATION; 2.22 NAPHTHOPYRAN SYNTHESIS; REFERENCES; 3 -- Carbon-Nitrogen Bond-Formation Reactions; 3.1 1,2-DIONE/DIAMINE CONDENSATION; 3.2 SYNTHESIS OF IMINES; 3.3 SYNTHESIS OF (THIO)SEMICARBAZONES; 3.4 SYNTHESIS OF OXIMES; 3.5 SYNTHESIS OF HYDRAZONES; 3.6 SYNTHESIS OF AZINES; 3.7 AMIDE AND THIOAMIDE BOND FORMATION |
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3.7.1 COUPLING OF ACTIVATED ACIDS AND AMINES3.7.2 ADDITION OF CUMULENES TO AMINES; 3.7.3 OXIDATIVE AMIDATION; 3.7.4 NUCLEOPHILIC ADDITION OF CARBOXYLATE; 3.7.5 CARBAMATE NITROGEN PROTECTION; 3.7.6 SYNTHESIS OF IMIDES; 3.8 SYNTHESIS OF NITRONES; 3.9 SYNTHESIS OF ENAMINES AND ENAMINE KETONES; 3.10 ALKYLATION OF NITROGEN; 3.11 SYNTHESIS OF BIGUANIDES AND GUANIDINES; 3.12 ADDITIONS TO DOUBLE AND TRIPLE BONDS; 3.12.1 AZA-MICHAEL REACTION; 3.12.2 AMINOHALOGENATION OF OLEFINS; 3.12.2.1 Aminochlorination of Olefins; 3.12.2.2 Aminobromination of Olefins; 3.12.3 INTRAMOLECULAR HYDROAMINATION |
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3.12.4 ADDITIONS TO IMINE BOND3.13 SUBSTITUTION REACTIONS; 3.14 N-ARYLATION OF AMINES; 3.15 BIGINELLI REACTION; 3.16 NITROSO BOND FORMATION/DISSOCIATION; REFERENCES; 4 -- CarbondOxygen and Other Bond-Formation Reactions; 4.1 CDO BOND FORMATION REACTIONS; 4.1.1 SYNTHESIS OF ETHERS; 4.1.1.1 Glycosylation; 4.1.1.2 O-Protection; 4.1.1.3 Cyclodehydration; 4.1.1.4 Epoxides; 4.1.2 ESTERS; 4.1.2.1 Alkylation; 4.1.2.2 Decarboxylative Esterification; 4.1.2.3 Transesterification; 4.1.2.4 Anhydride Ring Opening; 4.1.2.5 Tishchenko Reaction; 4.1.2.6 Acylation; 4.2 SULFUR BOND FORMATION REACTIONS |
| Subject |
Mechanical chemistry.
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Organic compounds -- Synthesis.
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Mécanochimie.
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Composés organiques -- Synthèse.
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SCIENCE -- Chemistry -- Physical & Theoretical.
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Mechanical chemistry
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Organic compounds -- Synthesis
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| Added Author |
trukil, Vjekoslav, author.
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| ISBN |
9780128025253 (electronic bk.) |
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0128025255 (electronic bk.) |
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9780128021842 |
| Standard No. |
AU@ 000061150446 |
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CHBIS 010796261 |
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CHVBK 403940311 |
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DEBSZ 482470429 |
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GBVCP 879393408 |
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