| Description |
1 online resource (425) |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Note |
Print version record. |
| Contents |
Front Cover; The Chemistry and Biology of Nitroxyl (HNO); Copyright Page; Contents; List of Contributors; Introduction: A Bit of History and General Facts About Nitroxyl: From Interstellar Molecule to Biological Gasotransmitter; References; 1 HNO: Redox Chemistry and Interactions With Small Inorganic Molecules; 1.1 Introduction; 1.2 Dimerization; 1.3 Reaction with molecular oxygen; 1.4 Reaction with NO; 1.5 Reaction with H2S; 1.6 Redox-related reactions; References; 2 HNO Donors: Angeli's Salt and Related Diazeniumdiolates; 2.1 Introduction; 2.2 Angeli's salt. |
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2.2.1 Synthesis and use of Angeli's salt2.2.2 Structural analysis; 2.2.3 Mechanism of decomposition; 2.2.4 Advantages and disadvantages; 2.3 Diazeniumdiolates; 2.3.1 Synthesis of primary amine diazeniumdiolates; 2.3.2 Structural analysis; 2.3.3 Mechanism of decomposition; 2.3.4 Advantages/disadvantages; 2.4 Diazeniumdiolate-based HNO-releasing prodrugs; 2.4.1 Synthesis of primary amine diazeniumdiolate ester derivatives; 2.4.2 Structural analysis; 2.4.3 Mechanism of decomposition; 2.4.4 Advantages/disadvantages; 2.5 Acyl nitroso compounds as HNO donors; 2.6 Conclusions; Acknowledgments. |
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AbbreviationsReferences; 3 Hydroxylamines With Organic-Based Leaving Groups as HNO Donors; 3.1 Introduction; 3.2 Synthesis; 3.3 Piloty's acid and its derivatives; 3.4 Cyanamide; 3.5 Hydroxylamines with carbon-bound leaving groups; 3.6 Summary; Acknowledgment; References; 4 Mechanistic Aspects of HNO Production from Hydroxylamine and Derivatives; 4.1 Hydroxylamine in chemical reactions; 4.2 Hydroxylamine derivatives and related compounds; 4.2.1 Hydroxylamine in biological systems; References; 5 HNO Generation From NO, Nitrite, Inorganic or Organic Nitrosyls, and Crosstalk With H2S. |
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5.1 HNO generation from NO and MNOn5.1.1 Basic considerations; 5.1.2 Metal-mediated processes; 5.1.2.1 Outer-sphere electron transfer; 5.1.2.2 Coordination and inner(outer)-sphere electron transfer; 5.1.2.2.1 MNO8 complexes; 5.1.2.2.2 MNO7 complexes and their reduction; 5.1.2.2.2.1 Heme/porphyrin MNO7 systems; 5.1.2.2.2.2 Low-spin nonheme MNO7 systems; 5.1.2.2.2.3 High-spin nonheme MNO7 systems; 5.1.2.2.3 MNO6 complexes; 5.1.2.3 Reduction by hydride; 5.1.2.4 Hydrogen atom transfer; 5.1.3 Metal-free processes; 5.1.3.1 Reduction of NO to HNO by vitamin C; 5.1.3.2 Reduction of NO to HNO by H2S. |
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5.2 HNO generation from nitrite and nitroso, NO+, species through the interplay with H2S and HSNO formation5.2.1 HNO generation through HSNO in the reaction of S-nitrosothiols or nitrite with H2S; 5.2.2 Metal-mediated HNO generation through HSNO in the reaction of nitrite or nitrosonium complexes with H2S; 5.2.2.1 Heme-catalyzed reaction between nitrite and H2S generates HSNO, HNO and NO; 5.2.2.2 Sodium nitroprusside with H2S generates HNO accompanied by conversion of toxic cyanide into thiocyanate; 5.3 Conclusion; References; 6 HNO-Thiol Relationship. |
| Note |
Includes index. |
| Summary |
Annotation The Chemistry and Biology of Nitroxyl (HNO), Third Edition, is completely updated with the latest trends, terminology, and applications in this fast-moving field. This comprehensive reference contains crucial foundational information that will help users understand the factors that control radical polymerization, along with practical content to support the design of polymer syntheses, and critical evaluation of the latest developments and their impact on research and practice. Covering vital processes that chemistry researchers, practitioners, and advanced students need to know, the book includes new content on the growing area of heterogeneous polymerization, including emulsion, miniemulsion, microemulsion, and dispersion polymerization. This new edition also explores recent progress in methods of control, including those not based on reversible deactivation radical polymerization or living radical polymerization. The coverage of RAFT polymerization has also been thoroughly updated to match the current IUPAC recommendation, as well as to correspond with this exciting area of active research. Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical researchProvides a valuable coverage of HNO s chemical structure and significant reactions, including practical guidance on working with this highly reactive moleculeContains high quality content from recognized experts in both industry and academia." |
| Subject |
Nitroso compounds.
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Nitrogen compounds.
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Nitroso Compounds |
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Nitrogen Compounds |
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Composés nitrosés.
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Azote -- Composés.
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nitrogen compounds.
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SCIENCE -- Chemistry -- Organic.
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Nitrogen compounds
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Nitroso compounds
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| Added Author |
Doctorovich, Fabio.
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Farmer, Patrick J.
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Marti, Marcelo A.
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| Other Form: |
Print version: Chemistry and biology of nitroxyl (HNO). Amsterdam, Netherlands : Elsevier, 2016, ©2017 9780128009345 0128009349 (OCoLC)935195294 |
| ISBN |
9780128011645 (electronic bk.) |
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0128011645 (electronic bk.) |
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9780128009345 |
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0128009349 |
| Standard No. |
AU@ 000061154562 |
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AU@ 000066135843 |
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AU@ 000068473705 |
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DEBSZ 482473509 |
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GBVCP 879400250 |
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