| Description |
1 online resource (xxiii, 546 pages) : illustrations (some color). |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Molecular medicine and medicinal chemistry ; 6 |
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Molecular medicine and medicinal chemistry ; 6.
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| Bibliography |
Includes bibliographical references and index. |
| Contents |
1. Synthesis and properties of fluorinated nucleobases in DNA and RNA / Holger Gohlke, Jelena Bozilovic and Joachim W. Engels -- 2. Molecular interactions of fluorinated amino acids within the hydrophobic core of a coiled coil peptide / Toni Vagt, Mario Salwiczek and Beate Koksch -- 3. Probing the binding affinity and proteolytic stability of trifluoromethyl peptide mimics as protease inhibitors / Matteo Zanda [and others] -- 4. Trifluoromethyl-substituted [symbol]-amino acids as solid-state [symbol]F NMR labels for structural studies of membrane-bound peptides / Vladimir S. Kubyshkin [and others] -- 5. Fluorine-containing pharmaceuticals / Steve Swallow -- 6. Applications of pentafluorosulfanyl substitution in life sciences research / John T. Welch -- 7. Strategic incorporation of fluorine into taxoid anticancer agents / Antonella Pepe, Liang Sun and Iwao Ojima -- 8. Synthesis and antiviral, antitumour activities of fluorinated sugar nucleosides / Feng Zheng, Xiao-Long Qiu and Feng-Ling Qing -- 9. Synthesis of fluorinated neurotransmitter analogues / Margit Winkler and David O'Hagan -- 10. [symbol]F-radionuclide chemistry / Romain Bejot and Veronique Gouverneur -- 11. [symbol]F-labelled tracers for PET oncology and neurology applications / Sajinder K. Luthra and Edward G. Robins -- 12. [symbol]F NMR: clinical and molecular imaging applications / Vikram D. Kodibagkar [and others]. |
| Summary |
Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging. This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For example, the reader will discover how fluorine has found its place as a key element in improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging. |
| Note |
Print version record. |
| Language |
English. |
| Subject |
Fluorine.
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Pharmaceutical chemistry.
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Fluorine -- chemistry |
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Fluorine -- diagnostic use. |
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Fluorine -- therapeutic use |
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Chemistry, Pharmaceutical |
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Fluorine |
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Fluor.
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Chimie pharmaceutique.
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MEDICAL -- Drug Guides.
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MEDICAL -- Nursing -- Pharmacology.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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Fluorine
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Pharmaceutical chemistry
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| Added Author |
Gouverneur, Véronique.
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Müller, Klaus.
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| Other Form: |
Print version: Fluorine in pharmaceutical and medicinal chemistry. London : Imperial College Press ; Singapore : Dist. by World Scientific Press, 2012 9781848166349 (OCoLC)751735680 |
| ISBN |
9781848166363 (electronic bk.) |
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1848166362 (electronic bk.) |
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1280668962 |
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9781280668968 |
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1848166346 (cloth) |
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9781848166349 (Cloth) |
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9786613645890 |
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6613645893 |
| Standard No. |
9786613645890 |
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AU@ 000049683599 |
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DEBBG BV043156305 |
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DEBSZ 372740065 |
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DEBSZ 423656082 |
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