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Title The spectrum of mineral and bone disorders in chronic kidney disease / edited by Klaus Olgaard, Isidro B. Salusky, Justin Silver.

Publication Info. Oxford ; New York : Oxford University Press, [2010]


Location Call No. OPAC Message Status
 Axe EBSCO Clinical Nursing E-Book  Electronic Book    ---  Available
Edition Second edition.
Description 1 online resource (xxvi, 590 pages) : illustrations (some color)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Oxford clinical nephrology series
Oxford clinical nephrology series.
Note Revised edition of: The spectrum of renal osteodystrophy / edited by Tilman Drüeke, Isidro B. Salusky. c2001.
Bibliography Includes bibliographical references and index.
Note Print version record.
Summary This new edition is fully updated to reflect the most current thinking and understanding in the field, as presented by a team of international clinical experts.
Contents Contributors; List of Abbreviations; Introduction; 1 Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD); Renal osteodystrophy; Chronic kidney disease-mineral bone disorder; Conclusion; References; 2 New aspects of normal bone biology; Introduction; Osteoclasts; Osteoblasts; Osteocytes; Systemic hormones; Summary; References; 3 Osteocytes and mineral metabolism; Introduction; The osteoblast/osteocyte lineage; Osteocyte role in mineralization; Roles of osteocytes in the control of Pi homeostasis
Osteocytes' role in phosphate dysregulation associated with CKDThe influence of CKD on osteocyte function; Summary; References; 4 Calcium-sensing receptors (CaSR) in kidney, bone, and vessels; Introduction; Expression, structure, and signaling of the extracellular CaSR; CaSR in the kidney; CaSR and bone; The CaSR and blood vessels; Summary; References; 5 Regulation of parathyroid hormone biosynthesis and gene expression; Introduction; Regulation of PTH expression by 1,25(OH)[sub(2)] vitamin D; Post-transcriptional regulation of PTH gene expression by calcium, phosphate, and CKD
Fibroblast growth factor-23 and PTH gene expressionConclusions; References; 6 Abnormal parathyroid gland function in CKD; Introduction; Regulation of PTH gene transcription in CKD; Regulation of PTH release in CKD; Phosphate and abnormal PTH synthesis and secretion in CKD; Vitamin D and abnormal PTH synthesis and secretion in CKD; Abnormal PTH synthesis and secretion due to other factors; Post-transcriptional modulation of PTH synthesis in CKD; Changes in the intracellular and peripheral metabolism of PTH in CKD; Hyperplasia of parathyroid glands in CKD
Parathyroid function and VDR polymorphismsControl of increased parathyroid mass; Parathyroid tissue apoptosis and necrosis; Summary; References; 7 PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor; Introduction; Characteristics of the PTHrP gene; Regulation of PTHrP production; Processing and degradation of PTHrP; Physiological actions of PTHrP; Mechanisms of action of PTHrP; PTH/PTHrP receptor expression in renal osteodystrophy; Summary; References; 8 Vitamin D metabolism and action in CKD; Introduction; 25-Hydroxyvitamin D deficiency in CKD; Calcitriol production in CKD
The vitamin D receptorEffects of declining 1,25-dihydroxyvitamin D on mineral metabolism; Non-traditional actions of vitamin D; Cardiac effects of calcitriol; Vitamin D and the immune system; Additional effects of vitamin D; Vitamin D and survival in CKD; Summary; References; 9 Growth factors and cytokines in renal bone disease; Introduction; The cells of bone; Bone remodeling; Effects of uremia on skeletal biology; References; 10 Bone histomorphometry in renal osteodystrophy; Historical perspective of renal osteodystrophy; Pathology of different forms of renal osteodystrophy
Language English.
Subject Renal osteodystrophy.
Chronic Kidney Disease-Mineral and Bone Disorder.
Renal Insufficiency, Chronic -- complications.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Renal osteodystrophy. (OCoLC)fst01094545
Chronische Niereninsuffizienz
Genre/Form Electronic books.
Electronic books.
Added Author Olgaard, Klaus.
Salusky, Isidro B.
Silver, Justin, 1943-
Added Title Spectrum of renal osteodystrophy.
Other Form: Print version: Spectrum of mineral and bone disorders in chronic kidney disease. Second edition 9780199559176 (DLC) 2010286038 (OCoLC)520713073
ISBN 9780191029325 (electronic bk.)
0191029327 (electronic bk.)
Standard No. AU@ 000062489719
AU@ 000062596274
DEBBG BV043032901
DEBSZ 421221879
GBVCP 813243963

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