| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Comprehensive analytical chemistry ; volume 71 |
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Comprehensive analytical chemistry ; v. 71.
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| Summary |
Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis deals with the use of high-resolution mass spectrometry (MS) in the analysis of small organic molecules. Over the past few years, time-of-flight (ToF) and Orbitrap MS have both experienced tremendous growth in a great number of analytical sectors and are now well established in many laboratories where high requirements are placed on analytical performance. This book gives a head-to-head comparison of these two technologies that compete directly with each other. As users with hands-on experience in both techniques, the authors provide a balanced description of the strengths and weaknesses of both techniques. In the vast majority of cases, ToF-MS and Orbitrap-MS have been used for qualitative purposes, mainly identification of discrete molecular entities such as drug metabolites or transformation products of environmental contaminants. This paradigm is now changing as quantitative capabilities are increasingly being explored, as are non-target approaches for unbiased broad-scope screening. In view of the continuous innovation of high-resolution MS instrument manufacturers in designing and developing more powerful machines, technological advances in both hardware and software are considerable, with many novel applications. This book summarizes and analyzes these trends. The compilation of selected examples from diverse analytical fields will allow the readers to discover not only the potential of high-resolution MS in their sector, but also shows advances in other fields that rely on hi-res MS. |
| Note |
Includes index. |
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Online resource; title from PDF title page (ScienceDirect, viewed June 10, 2016). |
| Contents |
Intro; Title page; Table of Contents; Advisory Board; Copyright; Contributors to Volume 71; Series Editor's Preface; Preface; Section I: Instrumentation; Section II: Target Analysis, Identification, and Suspect Screening; Section III: Nontarget Analysis; Section IV: Conclusions; Index; Chapter 1. Orbitrap Mass Spectrometry: Evolution and Applicability; Chapter 2. Advances in Time-of-Flight Mass Spectrometry; Chapter 3. Ambient Ionisation-High-Resolution Mass Spectrometry: Environmental, Food, Forensic and Doping analysis; Chapter 4. High-Resolution Mass Spectrometry in Doping Control |
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Chapter 5. Application of LC-Time-of-Flight and Orbitrap-MS/MS for Pesticide Residues in Fruits and VegetablesChapter 6. Identification of Sildenafil Designer Analogues Found in Dietary Supplements; Chapter 7. High-Resolution Mass Spectrometry in Metabolite Identification; Chapter 8. LC-TOF-MS for the Identification of Environmental Metabolites and Degradation Products; Chapter 9. Application of Orbitrap Mass Spectrometry for the Identification of Transformation Products of Trace Organic Contaminants Formed in the Environment |
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Chapter 10. High-Resolution Mass Spectrometry Identification of Micropollutants Transformation Products Produced During Water Disinfection With Chlorine and Related ChemicalsChapter 11. Discovery of New Emerging DBPs by High-Resolution Mass Spectrometry; Chapter 12. Suspect Screening of Pharmaceuticals and Related Bioactive Compounds, Their Metabolites and Their Transformation Products in the Aquatic Environment, Biota and Humans Using LC-HR-MS Techniques |
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2. Current Improvements in TOF Instrumentation3. GC/MS Instrumentation; 4. IM-TOF-MS Adding Additional Dimensionality; 5. Conclusion; 1. Introduction; 2. Ambient Ionisation Methods; 3. Ambient Mass Spectrometry Applications; 4. Concluding Remarks; 1. Introduction; 2. Targeted Analysis; 3. Untargeted Detection; 4. Conclusions; 1. Introduction; 2. Mass Resolution; 3. Mass Accuracy; 4. Workflows in Accurate Mass Spectrometry; 5. Comparison of Accurate Mass Spectrometry and Triple Quadrupole Mass Spectrometry; 6. Quantitative Analysis in Accurate Mass Spectrometry |
| Bibliography |
Includes bibliographical references and index. |
| Subject |
Time-of-flight mass spectrometry.
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Spectrométrie de masse à temps de vol.
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SCIENCE -- Chemistry -- Analytic.
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Time-of-flight mass spectrometry
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| Added Author |
Perez, Sandra, editor.
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Eichhorn, Peter, editor.
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Barceló, Damià, editor.
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| Other Form: |
Print version: 0444635726 9780444635723 (OCoLC)938383126 |
| ISBN |
9780444635730 (electronic bk.) |
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0444635734 (electronic bk.) |
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9780444635723 (print) |
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0444635726 |
| Standard No. |
GBVCP 879401443 |
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UKMGB 017889148 |
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