| Description |
1 online resource : illustrations |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Latest trends in palladium chemistry |
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Latest trends in palladium chemistry.
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| Bibliography |
Includes bibliographical references and index. |
| Note |
Online resource; title from PDF title page (EBSCO, viewed June 11, 2018). |
| Contents |
Front Cover; Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides; Copyright; Contents; Contributors; Chapter 1: The Future of Drug Discovery: The Importance of Modified Nucleosides, Nucleotides, and Oligonucleotides; 1. Introduction; 2. Biologically Active Modified Nucleosides; 3. Synthetic Fluorescent Nucleoside Analogs; 4. Oligonucleotide Applications; 5. An Overview of Other Cross-Coupling Reactions in This Book; 6. Stille Cross-Coupling; 7. Suzuki-Miyaura Cross-Coupling; 8. Sonogashira reactions; 9. Heck Cross-Coupling. |
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10. Buchwald-Hartwig reactions11. C-H Activation Reactions; 12. Cross-Coupling of Nucleotides and Oligonucleotides; 13. Summary and Future Directions; References; Chapter 2: Stille Cross-Coupling Reaction: Early Years to the Current State of the Art; 1 Introduction; 2. Stille Coupling Reactions; 2.1 Early Developments; 3 Conclusion; References; Chapter 3: Suzuki-Miyaura Cross-Coupling as a Synthetic Tool for Nucleoside and Nucleotide Modification; 1. Introduction; 2. Suzuki-Miyaura Reaction: Mechanism and Conditions; 2.1 Overview of the Reaction. |
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2.2 Suzuki-Miyaura Reaction in Various Water-Based Catalytic Systems2.2.1 In Tetrahydrofuran/Methanol/Water; 2.2.2 In Dimethylether/Water; 2.2.3 In DMF/H2O; 2.2.4 In ACN/H2O; 2.2.5 In MeOH/H2O; 2.2.6 In H2O; 3. Palladium-Catalyzed Suzuki-Miyaura Routes to Modified Nucleosides; 3.1 Purine Nucleoside Analogues; 3.1.1 Modified Nucleosides at Purine Moiety; 3.1.2 Modified Flexible Nucleosides; 3.1.3 Carbocyclic Nucleosides Analogues; 3.2 Pyrimidine-Modified Analogues; 3.2.1 Arylation at C5- and C6- of Uridine/Cytidine Moiety. |
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3.2.2 Arylation of C5-Halo Uridine/Cytidine and C7-Halo Purine Nucleotides3.3 Miscellaneous; 4. Concluding Remarks; Acknowledgments; References; Chapter 4: Sonogashira Cross-Coupling: Alkyne-Modified Nucleosides and Their Applications; 1. Introduction; 2. General Reaction and the Mechanism of Classical Sonogashira Reaction; 3. Modifications of Sonogashira Coupling; 3.1 Modifications of Ligated Pd-Catalysts; 3.2 Generation of Ligand-Free Palladium Catalysts; 3.3 Palladium Nanoparticles as Catalysts. |
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3.4 Modified Form of Cu(I)-Co-Catalyst: Click Reagent Version of Sonogashira Coupling: Contribution From Our Group3.5 Cu-Free Sonogashira Coupling; 3.6 Ligand, Copper, and Amine-Free Palladium Catalyzed Sonogashira Coupling; 4. Applications of the Sonogashira Reaction; 5. Sonogashira Reaction in the Synthesis of Nucleoside; 6. Application of Sonogashira Coupling to Pyrimidine Nucleosides; 6.1 Synthesis of C-4-Substituted Pyrimidines; 6.2 Synthesis of C-5-Substituted Pyrimidines; 7. Sonogashira Coupling for the Synthesis of Substituted Purine Nucleosides. |
| Summary |
Annotation This volume describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. |
| Subject |
Palladium catalysts.
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Nucleosides.
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Nucleotides.
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Oligonucleotides.
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Nucleosides |
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Nucleotides |
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Oligonucleotides |
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Catalyseurs au palladium.
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Nucléosides.
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Nucléotides.
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Oligonucléotides.
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SCIENCE -- Chemistry -- Physical & Theoretical.
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Nucleosides
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Nucleotides
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Oligonucleotides
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Palladium catalysts
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| Added Author |
Kapdi, Anant R., editor.
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Maiti, Debabrata, editor.
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Sanghvi, Yogesh S., 1956- editor.
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| Other Form: |
Print version: Palladium-catalyzed modification of nucleosides, nucleotides and oligonucleotides. Amsterdam, Netherlands : Elsevier, [2018] 9780128112922 0128112921 (OCoLC)1002834729 |
| ISBN |
9780128112939 (electronic bk.) |
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012811293X (electronic bk.) |
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9780128112922 |
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0128112921 |
| Standard No. |
AU@ 000062962802 |
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AU@ 000063914134 |
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AU@ 000069050286 |
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UKMGB 018870091 |
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