Schizophrenia : evolution and synthesis / edited by Steven M. Silverstein, Bita Moghaddam, and Til Wykes ; program advisory committee, Anil K. Malhotra, John McGrath, Andreas Meyer-Lindenberg, Bita Moghaddam, Steven M. Silverstein, Til Wykes.
Publication Info.
Cambridge, Massachusetts ; London, England : The MIT Press, [2013]
Includes bibliographical references (pages 307-380) and index.
Contents
Schizophrenia -- Heterogeneity -- What kind of a thing is schizophrenia? -- How the diagnosis of schizophrenia impeded the advance of knowledge (and what to do about it) -- What dimensions of heterogeneity are relevant for treatment outcome? -- Which aspects of heterogeneity are useful to translational success? -- Risk and resilience -- How should resilience factors be incorporated in treatment development? -- Insights into new treatments for early psychosis from genetic, neurodevelopment, and cognitive neuroscience research -- From epidemiology to mechanisms of illness -- How can risk and resilience factors be leveraged to optimize discovery pathways? -- Models -- Human cell models for schizophrenia -- How can animal models be better utilized? -- How can computational models be better utilized for understanding and treating schizophrenia? -- How can models be better utilized to enhance outcome? -- Development and treatment -- Why Kraepelin was right -- What will the next generation of psychosocial treatments look like? -- Creative solutions to overcoming barriers in treatment utilization -- What is necessary to enhance development and utilization of treatment?
Note
Print version record.
Summary
Despite major advances in methodology and thousands of published studies every year, treatment outcomes in schizophrenia have not improved over the last 50 years. Moreover, we still lack strategies for prevention and we do not yet understand how the interaction of genetic, developmental, and environmental factors contribute to the disorder. In this book, leading researchers consider conceptual and technical obstacles to progress in understanding schizophrenia and suggest novel strategies for advancing research and treatment.
