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Title MicroRNAs in development and cancer / editor Frank J. Slack.

Imprint London : Imperial College Press ; Singapore : World Scientific [distributor], 2011.


Location Call No. OPAC Message Status
 Axe EBSCO Clinical Nursing E-Book  Electronic Book    ---  Available
Description 1 online resource (xv, 282 pages) : illustrations (some color)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Molecular medicine and medicinal chemistry ; v. 1
Molecular medicine and medicinal chemistry ; v. 1.
Bibliography Includes bibliographical references and index.
Contents Introduction to gene regulation by small RNAs -- The emerging non-coding RNA world -- MicroRNAs in C. elegans development -- MicroRNAs in mammalian development -- MicroRNAs in hematopoietic development -- MicroRNAs function as tumor suppressor genes and oncogenes -- Simultaneous detection of primary, precursor and mature microRNAs by qPCR -- Single nucleotide polymorphisms in microRNAs and microRNA binding sites with roles in cancer -- MicroRNAs as potential diagnostics and therapeutics -- MicroRNA target prediction -- Non-coding RNAs in cancer: the other part of the story.
Summary "MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer."--Page 4 of cover.
Note Print version record.
Subject Small interfering RNA.
Neoplasms -- genetics.
Neoplasms -- therapy.
Biomarkers, Tumor.
Gene Expression Regulation.
MEDICAL -- Oncology.
Cancer. (OCoLC)fst00845317
Small interfering RNA. (OCoLC)fst01121445
Genre/Form Electronic books.
Added Author Slack, Frank J.
Other Form: Print version: MicroRNAs in development and cancer. London : Imperial College Press ; Singapore : World Scientific [distributor], 2011 9781848163669 (OCoLC)298781535
ISBN 9781848163676 (electronic bk.)
1848163673 (electronic bk.)
Standard No. AU@ 000047752791
AU@ 000050968205
AU@ 000051395121
AU@ 000058165531
DEBBG BV044156389
DEBSZ 397097476
DEBSZ 421584084
DEBSZ 456484078
HEBIS 286063565
NZ1 14167170

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