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Title Neurological disorders : new research / Chloe E. Thomas and Jayden R. Moore, editors.

Publication Info. New York : Nova Biomedical, Science Science Publishers, Incorporated, [2012]
©2012

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Location Call No. OPAC Message Status
 Axe EBSCO Clinical Nursing E-Book  Electronic Book    ---  Available
Description 1 online resource
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Neuroscience research process
Neurology--laboratory and clinical research developments
Bibliography Includes bibliographical references and index.
Note Print version record and cip data provided by publisher.
Contents NEUROLOGICAL DISORDERS ; NEUROLOGICAL DISORDERS ; Contents; Preface; Advanced Structural and Functional MRI Techniques in Parkinson's Disease; Abstract; Introduction; MR Morphometry; Diffusion MR Imaging; Functional MRI; Motor fMRI; Cognitive fMRI; Resting-State fMRI; Conclusion; References; Neuropoietic Cytokines and Neural Injury: Alterations in JAK2/STAT3 Signaling Associated with Aging; Abstract; 1. Introduction; 1.1. Neuropoietic Cytokine Family; 1.2. Role of the gp130 Cytokine Receptor Complex; 1.3. Role of Janus Kinases (Jaks)
1.4. Activation of Signal Transducer and Activator of Transcription 3 (STAT3)1.5. Effects of Phospho-STAT3 (pSTAT3); Cell Survival; Remodeling the Cellular Environment; Regulating Oxidative Stress; Immune Tolerance; Role of the Phosphorylation Site; 1.6. Regulating pSTAT3: Role of Negative Regulators; Suppressors of Cytokine Signaling (SOCS); Protein Inhibitors of Activated Stats (PIAS); Protein Tyrosine Phosphatases (PTP); 2. Discussion; 2.1. Changes in Neural Injury; Stroke; Traumatic Brain Injury; 2.2. JAK2/STAT3 Regulation Altered with Aging; 2.3. Significance of Phosphorylation Site.
3. Future Directions3.1. Elucidate the Role of STAT3 across Cell Types; 3.2. Modulating Beneficial vs. Detrimental Effects; 3.3. Identifying Injury-Associated Changes; 3.4. Understanding and Manipulating Regulatory Processes for Therapeutic Benefit; 3.5. The IL-6 and IL-10 Signaling Dynamic; 3.6. Therapeutic Development: Challenges of Inhibition; Conclusion; Acknowledgments; References; Neurological Complications Associated with Anti-Tumor Necrosis Factor Alpha (TNF-A) Treatment; Abstract; Introduction; Tumor Necrosis Factor (TNF)-A; Pathogenicity of TNF-A in Neurological Disorder.
Anti-TNF-A or TNF-A Antagonist DrugAnti-TNF-A and Neurological Disorders; Conclusion; References; Effect of Aging on Changes of Nociception and Cav2 1 Expression Patterns in Seven Inbred Mouse Strains; Abstract; Introduction; Materials and Methods; Animals; Nociceptive Assays; Statistical Analysis of Behavioral Tests; Real-Time qRT-PCR Analysis; Results; Pain-Related Behavioral Tests; Expression Tests of Cav2 Family Members with Real-Time qRT-PCR Assay; Discussion; Conclusion; Acknowledgments; References; Polymeric Intracorporeal Devices for the Management of Neurological Disorders.
Abstract1. Introduction; 2. Polymer-Based Implantable Devices for Major CNS Disorders; 2.1. Intracranial Implants; 2.1.1. Drug Delivery Approaches Employed to Traverse the Blood Brain Barrier; 2.1.1.1. Ethylene Vinyl Acetate Copolymers Avac as a Prototype; Biocompatible Polymer Employed for Local Drug Delivery to the Brain; 2.1.1.2. Silk-Based Polymers as an Alternative to Synthetic Drug Delivery-Systems for the Treatment of Epilepsy; 2.1.2. Application of Polymer-Based Implantable Devices in Parkinson's Disease; 2.1.2.1. Biocompatible Dopamine-Loaded Polymeric Matrix Device.
Subject Nervous system -- Diseases.
Neurology.
Nervous System Diseases
Neurology
Système nerveux -- Maladies.
Neurologie.
HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain)
MEDICAL -- Neurology.
Nervous system -- Diseases
Neurology
Added Author Thomas, Chloe E., editor.
Moore, Jayden R., editor.
Other Form: Print version: Neurological disorders. New York : Nova Biomedical, Science Science Publishers, Inc., [2012] 9781622570423 (DLC) 2012939016
ISBN 9781622570560 (ebook)
1622570561
9781622570423 (hardcover)
1622570421
Standard No. DEBBG BV041049537

 
    
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