| Description |
1 online resource (xxv, 671 pages) : illustrations |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Bibliography |
Includes bibliographical references and index. |
| Note |
Print version record. |
| Contents |
Contributors; Preface; Chapter 1 Pathology of Prostate Lawrence True and Funda Vakar-Lopez; Introduction; Prostate Anatomy; Prostate "Capsule"; Zones of the Prostate; Cell Types of the Prostate; Benign Prostatic Hypertrophy (BPH); Inflammation; Granulomatous Prostatitis; Chronic Prostatitis; Pre-Neoplastic Lesions; Prostatic Intraepithelial Neoplasia (PIN); Other Candidate Pre-Neoplastic Lesions; Prostate Carcinoma; Diagnosis of Prostate Cancer; Differential Diagnostic Considerations; Grading Prostate Carcinoma; Tertiary Gleason pattern; Percentage of Gleason patterns. |
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Grade progressionSpindle Cell Lesions; Non-Prostate Spindle Cell Lesions; Prostate Spindle Cell Lesions; Sarcoma of Prostate; Carcinosarcoma (Sarcomatoid Carcinoma) of Prostate; Pathology of Non-Surgical Therapy; Radiation Therapy; Androgen Deprivation (Blockade) Therapy; Neoadjuvant Therapy; Recommendations for Pathology Reports; Needle Biopsy Reports; Radical Prostatectomy Reports; Surgical margin; Extraprostatic extension; Lymph node dissection; Tissue Biomarkers; Future Trends; References; Chapter 2 Genetic Basis for Prostate Cancer Stacy Loeb and William B. Isaacs; Introduction. |
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Family-Based StudiesGenome-Wide Association Studies; Future Directions; Conclusions; References; Chapter 3 Androgen Receptor Converts from a Growth Suppressor in the Normal Prostate to an Oncogene in Prostate Cancer Donald J. Vander Griend and John T. Isaacs; Introduction; Androgen Receptor Suppresses the Growth of Normal Prostate Epithelial Cells; Androgen Receptor Functions as an Oncogene in Prostate Cancer; Clinical Implications of AR Conversion from a Growth Suppressor to an Oncogene; Loss of AR-Mediated Growth Suppression Without Gaining Oncogenic Ability; Acknowledgments; References. |
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Chapter 4 Etiology: Role of ETS Factor Gene Fusions Jianghua Wang and Michael IttmannIntroduction; ETS Transcription Factor Gene Fusions in Prostate Cancer; Structure and Transcription of the TMPRSS2/ERG Fusion Gene; Origin of the TMPRSS2/ERG Fusion Gene; Alternative Splicing of the TMPRSS2/ERG Fusion Transcript; Pathological Correlations; The ETS Transcription Factor Gene Family; Biological Activities of the ERG and T/E Fusion Gene Protein; Association of T/E Fusion Gene Expression with Global Gene Expression and Copy Number Alterations in Prostate Cancer. |
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Genetics of TMPRSS2/ERG Prostate CancerClinical Implications of the TMPRSS2/ERG Fusion Gene; Summary; References; Chapter 5 Etiology of Prostate Cancer: Role of Inflammation William G. Nelson, Angelo M. DeMarzo and Srinivasan Yegnasubramanian; Introduction; Inflammation in the Human Prostate and Prostate Cancer; Sex Steroid Hormones and Inflammation in the Prostate; Infections and Inflammation in the Prostate; Inflammation and Inherited Susceptibility to Prostate Cancer; The Diet and Inflammation in the Prostate; Inflammation and the Molecular Pathogenesis of Prostate Cancer. |
| Summary |
This book effectively summarizes our knowledge of recent advances in prostate cancer. It focuses on our state-of-the-art understanding of risk factors, prevention, detection, prognosis and treatment of prostate cancer and identifies basic science findings that are being translated into clinical practice. In addition, the book singles out key areas of research that have potential for clinical translation. Both basic scientists and clinicians will be invited to provide up-to-date reviews in each area of prostate cancer. During the last decade the pace of clinical discovery and the scientific advances in prostate cancer have been very rapid. For instance, currently there are more than 100 drugs in the pharmaceutical pipeline that have the potential for clinical management of prostate cancer. Therefore, it has been very difficult for clinicians and basic scientists to keep pace with the field as a whole. Recently, some of these discoveries are already having an impact on clinical practice. For example, the discovery of the androgen receptor gene amplification in prostate cancer has led to the development of a "super-antiandrogen", which is being tested in clinical trials. Also, recent knowledge of androgen synthesis in prostate cancer cells has led to clinical trials with steroid-metabolism inhibitors. Finally, robotic surgery has also dramatically changed clinical practice. Thus, this important book serves to provide readers with a one-stop overview of the field of prostate cancer research and its translation into the clinical arena |
| Subject |
Prostate -- Cancer.
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Prostate -- Cancer -- Diagnosis.
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Prostate -- Cancer -- Treatment.
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Prostatic Neoplasms -- diagnosis |
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Prostatic Neoplasms -- therapy |
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Prostatic Neoplasms |
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Prostate -- Cancer.
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Prostate -- Cancer -- Traitement.
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HEALTH & FITNESS -- Diseases -- Cancer.
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MEDICAL -- Oncology.
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Prostate -- Cancer
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Prostate -- Cancer -- Diagnosis
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Prostate -- Cancer -- Treatment
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| Added Author |
Scardino, Peter T.
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| Other Form: |
Print version: Tindall, Donald. Recent advances in prostate cancer. Singapore : World Scientific Publishing, 2011 9789814329453 (DLC) 2011499696 (OCoLC)755875175 |
| ISBN |
9789814329460 (electronic bk.) |
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9814329460 (electronic bk.) |
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1283433559 |
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9781283433556 |
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9789814329453 |
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9814329452 |
| Standard No. |
AU@ 000051588711 |
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AU@ 000058371759 |
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DEBBG BV043150027 |
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DEBSZ 421459131 |
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NZ1 14694080 |
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