Description |
1 online resource (359 pages) : illustrations (some colors). |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
Series |
Cancer etiology, diagnosis, and treatments |
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Cancer etiology, diagnosis, and treatments.
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Bibliography |
Includes bibliographical references and index. |
Note |
Print version record. |
Contents |
CHRONIC MYELOID LEUKEMIA: FROM DAILY MANAGEMENT TO COMPLICATED ISSUES; Library of Congress Cataloging-in-Publication Data; Contents; Preface; In Memorium; Section I; Chapter I: Definition, Epidemiology, Natural History and Clinical Phases; Abstract; Introduction; Epidemiology; Risk Factors; Natural History; Clinical Phases; References; Section II; Chapter II: CML: Clinical Diagnosis, Differential Diagnosis and Scoring Systems; Abstract; Introduction; CML Scoring Systems of Disease Prognosis; Differential Diagnosis of CML; References. |
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Chapter III: Chronic Myelogenous Leukemia, Morphology and ImmunophenotypeAbstract; Introduction; Chronic Phase; Accelerated Phase; Blast Crisis; Differential Diagnoses; Flow Cytometric Immunophenotyping; Conclusion; References; Chapter IV: Cytogenetic and Molecular Aspects of CML; Abstract; Introduction; Molecular Basis of CML; Cytogenetic and Molecular Testing Methods; Cytogenetic Findings in CML; Cytogenetic and Molecular Testing; Diagnosis; Minimal Residual Disease Monitoring; TKI Resistance Testing; Conclusion; References; Chapter V: Molecular Mechanisms in CML Pathogenesis; Abstract. |
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IntroductionThe BCR-ABL Oncogene; BCR-ABL Causes Aberrant Signaling in CML; Changes in Telomeres and Telomerases in CML; Genetic Alterations in CML; Pathogenesis of Transformation; The CML Stem Cell; References; Chapter VI: Secondary Resistance to Tyrosine Kinase Inhibitors: Focus on Molecular Mechanisms other than BCR-ABL Overexpression and Mutations; Abstract; Introduction; 1. Drug Transporters; 2. Signalling Pathways Included in CML Resistance to TKIs -- Towards "BCR-ABLIndependence""; 3. Role of Multifunctional (proto-)oncogenes and Tumor Suppressors in CML Resistance to TKIs. |
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4. Programmed Cell Death Capacity of CML Cells -Autophagic Cell Death and Responsiveness to Imatinib (TKIs)5. Mitochondria and Metabolism in CML Cells; 6. Sensitivity of Primitive CD34+ CML Cells to Tyrosine Kinase Inhibitors; Summary and Discussion; References; Section III; Chapter VII: Frontline Therapy; Abstract; Introduction; Pathophysiology of CML; Management of CML; Pharmacotherapy for CML; Monitoring Treatment Response; Monitoring for Minimal Residual Disease (MRD); Improving Treatment Outcomes in the Frontline Setting; TKIs -- Fertility and Pregnancy; Conclusion; References. |
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Chapter VIII: Management of Tyrosine Kinase Inhibitors ResistanceAbstract; Introduction; Defining Lack of Response to TKI Therapy and Treatment Failure; Pathophysiology and Causes of Treatment Failure; Primary Resistance; BCR-ABL Dependent Mechanisms; BCR-ABL-Independent Mechanisms of Resistance; Molecular Monitoring for Resistance; Management of TKI Resistance; Third Line Therapy; Newer Therapies; Role of HSCT; References; Chapter IX: Management of Chronic Myeloid Leukemia (CML): Accelerated Phase(AP); Abstract; Introduction; Accelerated Phase: Diagnostic Criteria. |
Subject |
Chronic myeloid leukemia.
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Blood -- Diseases.
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Cancer.
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
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Hematologic Diseases |
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Neoplasms |
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Leucémie myéloïde chronique.
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Sang -- Maladies.
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Cancer.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Blood -- Diseases
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Cancer
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Chronic myeloid leukemia
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Added Author |
Ustun, Celalettin.
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Popat, Uday R.
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Other Form: |
Print version: Chronic myeloid leukemia : from daily management to complicated issues. Hauppauge, NY : Nova Science Publishers, Inc., [2014] x, 345 pages Cancer etiology, diagnosis and treatments 9781629489711 (DLC) 17961924 |
ISBN |
9781629489926 (e-book) |
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1629489921 (e-book) |
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9781629489711 (hardcover) |
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1629489719 |
Standard No. |
AU@ 000056896546 |
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AU@ 000065259156 |
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