| Description |
1 online resource (xxiii, 354 pages) : illustrations |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Summary |
This book will provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R & D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R & D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes |
| Contents |
Foreword by K. Barry Sharpless. Foreword by Jerome L. Moniot. Preface. About the Author. Approaches to Process Development. Route Selection. Reagent Selection. Solvent Selection. Running the Reaction. Effects of Water. In-Process Controls. Optimizing the Reaction by Minimizing Impurities. Optimizing Catalytic Reactions. Work-Up. Tools for Purifying the Product: Column Chromatography, Crystallization, and Reslurrying. Final Product Form and Impurity Considerations. Vessels and Mixing. Preparing for and Implementing the Scale-up Run. Troubleshooting. Chiral Syntheses. General Index. Reaction Type Index. Reagent Index. |
| Bibliography |
Includes bibliographical references and indexes. |
| Note |
Print version record. |
| Subject |
Chemical processes.
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Procédés chimiques.
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TECHNOLOGY & ENGINEERING -- Chemical & Biochemical.
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SCIENCE -- Chemistry -- Industrial & Technical.
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Chemical processes
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Procesindustrie.
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Chemische industrie.
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Farmaceutische industrie.
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Procestechnologie.
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Research and Development.
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Procesbeheersing.
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Processos químicos.
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| Added Title |
Practical process research and development |
| Other Form: |
Print version: Anderson, Neal G. Practical process research & development. San Diego : Academic Press, ©2000 0120594757 9780120594757 (DLC) 99067291 (OCoLC)43541954 |
| ISBN |
9780120594757 |
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0120594757 |
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9780080514482 (electronic bk.) |
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0080514480 (electronic bk.) |
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1281024058 |
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9781281024053 |
| Standard No. |
AU@ 000054162548 |
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CHNEW 001005286 |
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DEBBG BV039830557 |
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DEBBG BV042315533 |
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DEBBG BV043044563 |
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DEBSZ 367751755 |
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DEBSZ 422200301 |
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NZ1 12434030 |
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