| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Note |
Vendor-supplied metadata. |
| Bibliography |
Includes bibliographical references. |
| Summary |
Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity. |
| Contents |
Front Cover; Advances in Structure and Activity Relationship of Coumarin Derivatives; Copyright Page; Contents; List of Contributors; 1 Introduction to Coumarin and SAR; 1.1 What is Coumarin?; 1.2 Types of Coumarin and Examples; 1.3 What is SAR?; 1.4 Why SAR?; 1.5 Application of SAR; 1.5.1 Pharmacokinetics Studies Via SAR; 1.5.2 Drug-Receptor Interaction Studies Using SAR; 1.5.3 Chemical, Physical Property and Formulation; 1.5.4 Drug Modification; 1.5.5 Toxicity Studies Using SAR; 1.6 When SAR Studies are Done; 1.6.1 Screening; 1.6.2 Lead Molecule; 1.6.3 Pruning; 1.6.4 Pharmacophore |
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1.6.5 Mechanism of Interaction with Target Site1.6.6 Structure-Activity Relationships; 1.6.7 Lead Optimization; 1.7 Needs of SAR; 1.8 SAR of Coumarin in Disease Biology; 1.9 Summary; 2 Antimicrobial Agents; 2.1 Introduction; 2.2 What is an Antibacterial Agent?; 2.2.1 Functional Group at C3 Position; 2.2.1.1 Alkyl Chain; Carboxylic Group with Alkyl Chain; Amide Group with Alkyl Chain; 2.2.1.2 Carbonyl and Alkoxyimino Group; 2.2.1.3 Amide and Hydroxamate Groups; 2.2.1.4 Benzyl Group with Different Substitution; t-Butyl Group; Hydroxyl Group; Methoxy Group; Halide Group |
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2.2.2 Functional Group at C4 Position2.2.2.1 Small Aliphatic Group (CH3); 2.2.2.2 Iodinated Aryloxymethyl Coumarin; 2-Idophenol Group; 3-Idophenol Group; 4-Idophenol Group; 2.2.2.3 Sulphur Derivatives; 2.2.3 Functional Group at C5 Position; 2.2.3.1 Amine Group; 2.2.3.2 Nitro Group; 2.2.4 Functional Group at C7 Position; 2.2.4.1 Alkenyl and Alkynyl Group; 2.2.4.2 Carbamoyl Group; 2.2.4.3 Complex Alkoxy Group; Electron-Withdrawing Group; 2.2.4.4 Phenyl Group; 2.2.4.5 Biphenyl Group; Napthyl and Anthracenyl Group; Pyridyl Group; Quinolinyl or Isoquinolinyl Group |
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2.2.5 Fused Ring at C6-C7 Position2.2.5.1 Furan Ring; Substitution on Furan Ring; 2.2.6 Functional Group at C8 Position; 2.2.6.1 Dimethyl Group with One Methyl Group at C7 Position; 2.2.6.2 Ethyl Group; 2.3 Antiviral Agents; 2.3.1 Planarity of Molecules; 2.3.2 Functional Group on Coumarin Nucleus; 2.3.2.1 Small Aliphatic Group; 2.3.3 Functional Group at C3 Position; 2.3.3.1 Benzimidazole-Coumarin with Various Substituents; Methyl Group; Aromatic Group; D-ribofuranose Group; 2.3.3.2 SCH2 Linkage; Benzoxazole and Benzothiazole Group; Imidazopyridine Group; Benzimidazole Group; Guanosine Group |
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Adenosine GroupPurine Ribofuranoside Group; Purine Ribofuranoside with Free -OH Group; 2.4 Antifungal Agents; 2.4.1 Functional Group at C3 Position; 2.4.1.1 Nitro Group; 2.4.2 Functional Group at C4 Position; 2.4.2.1 Acetyl Group; 2.4.3 Functional Group at C6 Position; 2.4.3.1 Ether Group; 2.4.3.2 Acetyl Group; 2.4.3.3 Nitro Group; 2.4.4 Functional Group at C7 Position; 2.4.4.1 Hydroxy Group; Small Aliphatic Chain; Prenyl Group; Large Chain; 2.4.4.2 Acetyl Group; 2.4.4.3 Nitro Group; 2.4.4.4 Thiosemicarbazide and Thiazolidinone Group; Phenyl Group; 3 Antitumor Agents; 3.1 Introduction |
| Subject |
Coumarins.
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Coumarins -- Derivatives.
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Coumarins |
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Coumarines.
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Coumarines -- Dérivés.
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SCIENCE -- Chemistry -- Organic.
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Coumarins
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| Added Author |
Penta, Santhosh, editor.
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| ISBN |
9780128038734 (electronic bk.) |
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012803873X (electronic bk.) |
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9780128037973 |
| Standard No. |
AU@ 000056951841 |
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CHBIS 010796034 |
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CHVBK 403939844 |
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DEBSZ 482467339 |
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GBVCP 879390158 |
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UKMGB 017568171 |
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