| Description |
1 online resource. |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Pharmacology - research, safety testing and regulation |
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Pharmacology-research, safety testing, and regulation series.
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| Bibliography |
Includes bibliographical references and index. |
| Contents |
DIAZEPAM MEDICAL USES, PHARMACOLOGY AND HEALTH EFFECTS; DIAZEPAM MEDICAL USES, PHARMACOLOGY AND HEALTH EFFECTS; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter I Diazepam and the Developing Brain: Consequences of an Early Chronic Exposure on Brain Plasticity, Cerebral Functionality and Behavior; Abstract; 1. Introduction; 2. Potential Teratogenicity of Diazepam; 3. Neonatal Complications Consecutive to Diazepam Exposure during Late Pregnancy; 4. Long-Lasting Neurobehavioral Toxicity Related to Early Exposure to Diazepam. |
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4.1. The Brain of the Fetus and of the Neonate: A Target for the Action of DZ4.2. Vulnerability of the Developing Brain to Early DZ Exposure: Results from Human and Animal Studies; a) Human Studies; b) Animal Studies; 4.3. Short- and Long-term Brain and Behavior Toxicity of a 3-Week Postnatal Administration of DZ in Rat Pups; a) Animals and Pharmacological Treatment; b) Blood and Brain Concentrations of DZ and N-desmethyldiazepam; c) Effects of DZ on Body and Brain Growth; d) Short-term Effects of DZ Exposure; e) Long-term Effects of DZ Exposure; f) Conclusion. |
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4.4. Potential Mechanisms of Action of DZ during Early Brain DevelopmentConclusion; References; Chapter II Diazepam in Anxiolytic Animal Therapy ; Abstract; Introduction; Mechanism of Action; General Benzodiazepine Use; Diazepam and Its Clinical Use in Veterinary Medicine; Use of Diazepam for Anxiety-Related Behavior Disorders; Conclusion; References; Chapter III Diazepam: Principal Indications Related with its Molecular Actions and Advantages and Gerardo Barragán Mejía2; Abstract; Introduction; Origin; Pharmacokinetics; Characteristic Actions; Duration of Action; Benzodiazepines Abuse. |
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Anticonvulsant IndicationUse in Children; Anxiolitic Action; Adverse Effects; Drug interactions; Oxidative Stress; Therapeutic Drug Monitoring; References; Chapter IV Diazepam-Like Effects of Medicinal Plants: A Possible Approach or a Complementary Method?; Abstract; 1. Introduction; 2. Data Collection; 3. Diazepam-Like Activity Plants; 4. A Possible Approach or a Complementary Method?; Conclusion; Competing Interests; Authors' Contributions; Acknowledgments; References; Chapter V Anxiety/Depression-Related Animal Models: Zebrafish and Diazepam ; Abstract; Introduction; Model Development. |
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Novel vs. Familiar, Open Field, Social Isolation TestsPharmacological Models for Anxiety/Depression-like Responses; Model Limitations; References; Index. |
| Summary |
Since their introduction to the market in the 1960s, benzodiazepines, and among them diazepam, have become one of the most frequently prescribed psychotropic drugs in industrial countries. These compounds are known for their sedative, hypnotic, anxiolytic, muscle-relaxant and anticonvulsant properties and their large therapeutic index. In this book, the authors present current research in the study of the medical uses, pharmacology and health effects of diazepam. Topics discussed include the consequences of early chronic exposure to diazepam on brain plasticity, cerebral functionality and beha. |
| Subject |
Diazepam.
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Diazapam. |
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Diazepam |
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Diazépam.
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MEDICAL -- Pharmacology.
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Diazepam
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| Added Author |
Walker, Harold M., editor.
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Torres, Paul A., editor.
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| Other Form: |
Print version: Diazepam New York : Nova Biomedical [2014] (DLC) 2013953813 |
| ISBN |
9781629486284 ebook |
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1629486280 |
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1629486272 pbk. |
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9781629486277 pbk. |
| Standard No. |
DEBBG BV042794281 |
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