| Edition |
1st ed. |
| Description |
1 online resource (xiii, 381 pages) : illustrations (some color). |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Perspectives in bioanalysis ; v. 2 |
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Perspectives in bioanalysis ; v. 2.
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| Summary |
Since the independent invention of DNA sequencing by Sanger and by Gilbert 30 years ago, it has grown from a small scale technique capable of reading several kilobase-pair of sequence per day into today's multibillion dollar industry. This growth has spurred the development of new sequencing technologies that do not involve either electrophoresis or Sanger sequencing chemistries. Sequencing by Synthesis (SBS) involves multiple parallel micro-sequencing addition events occurring on a surface, where data from each round is detected by imaging. New High Throughput Technologies for DNA Sequencing and Genomics is the second volume in the Perspectives in Bioanalysis series, which looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century. Reviews of complementary developments in Sanger and SBS sequencing chemistries, capillary electrophoresis and microdevice integration, MS sequencing and applications set the framework for the book. * 'Hot Topic' with DNA sequencing continuing as a major research activity in many areas of life science and medicine. * Bringing together new developments in DNA sequencing technology * Reviewing issues relevant to the new applications used. |
| Contents |
Overview : developments in DNA sequencing / Keith R. Mitchelson [and others] -- Chip capillary electrophoresis and total genetic analysis systems / Quiang Xiong and Jing Cheng -- Comparative sequence analysis by MALDI-TOF mass spectrometry : utilizing the known to discover the new / Mathias Ehrich, Franz Hillenkamp, and Dirk van den Boom -- Advances in dye-nucleotide conjugate chemistry for DNA sequencing / Shiv Kumar and Carl W. Fuller -- The 454 life sciences picoliter sequencing system / Marcel Margulies [and others] -- An integrated system for DNA sequencing by synthesis / John R. Edwards, Dae Hyun Kim, and Jingyue Ju -- Single-molecule fluorescence microscopy and its applications to single-molecule sequencing by cyclic synthesis / Benedict Hebert and Ido Braslavsky -- Rapid DNA sequencing by direct nanoscale reading of nucleotide bases on individual DNA chains / James Weifu Lee and Amit Meller -- A single molecule system for whole genome analysis / Shiguo Zhou, Jill Herschleb, and David C. Schwartz -- Sequencing aided by mutagenesis facilitates the de novo sequencing of megabase DNA fragments by short read lengths / Jonathan M. Keith [and others] -- Genome sequencing and assembly / Annette McGrath -- Valid recovery of nucleic acid sequence information from high contamination risk samples : ancient DNA and environmental DNA / George A. Kowalchuk [and others]. |
| Bibliography |
Includes bibliographical references and index. |
| Note |
Print version record. |
| Subject |
Nucleotide sequence -- Technological innovations.
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Genomics -- Technological innovations.
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Genetic engineering -- Technological innovations.
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Sequence Analysis, DNA -- methods |
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Genomics -- methods |
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Genetic Engineering -- methods |
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Génomique -- Innovations.
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| Added Author |
Mitchelson, Keith R., editor.
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| Other Form: |
Print version: New high throughput technologies for DNA sequencing and genomics. 1st ed. Amsterdam ; Boston : Elsevier, 2007 0444522239 9780444522238 (DLC) 2006050864 (OCoLC)73994456 |
| ISBN |
9780444522238 |
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0444522239 |
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0080471285 (electronic bk.) |
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9780080471280 (electronic bk.) |
| Standard No. |
AU@ 000048131116 |
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CHDSB 005985568 |
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DEBBG BV039828491 |
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DEBBG BV042304764 |
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DEBSZ 405310242 |
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DEBSZ 482356022 |
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NZ1 11778545 |
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NZ1 15188751 |
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