Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
Series |
Neuroscience research progress |
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Neuroscience research progress.
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Bibliography |
Includes bibliographical references and index. |
Note |
Print version record. |
Contents |
MYOTONIC DYSTROPHIES EPIDEMIOLOGY, DIAGNOSIS AND THERAPEUTIC CHALLENGES ; MYOTONIC DYSTROPHIES EPIDEMIOLOGY, DIAGNOSIS AND THERAPEUTIC CHALLENGES ; Contents ; Preface ; Chapter 1 Epidemiology of Myotonic Dystrophy in the Molecular Era: Implications for Clinical Trials and Association Studies ; Abstract ; Introduction ; The Population Origins of DM1 ; The Epidemiology of DM1 ; The Epidemiology of DM2 ; Implications for Clinical Trials and Association Studies ; Conclusion ; References ; Chapter 2 Detecting and Targeting RNA: Biomarkers and Therapy for Myotonic Dystrophy ; Abstract |
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Introduction Development of Biomarkers for Myotonic Dystrophy Type 1 (DM1) ; Blood-based Biomarkers ; Tissue Biomarkers ; Cerebrospinal Fluid Biomarkers ; Potential Therapeutic Applications for DM1 ; Targeting the Pathogenic DM1 RNA Transcripts ; Exogenous Induction of MBNL1 and CUGBP1 Protein Activity ; Conclusion; References; Chapter 3 Endocrine System Involvement in Myotonic Dystrophy: Emerging Interactions and Potential Therapeutic Strategies ; Abstract; Introduction ; Parathyroid and Thyroid-Related Hormones ; Vitamin D ; Insulin Resistance and Metabolic Syndrome |
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Adrenocortical Activity Hypogonadism and Fertility ; Conclusion ; References ; Chapter 4 Central Nervous System Involvement in Myotonic Dystrophies ; Abstract ; Introduction ; Cognitive Impairment in Myotonic Dystrophy Type 1 (DM1, Steinert's Disease) ; Cognitive Involvement in DM2 ; Sleep Related Disorders in DM1 and DM2 ; Conclusion ; References ; Chapter 5 Strategies for Neuromuscular Blockade in Patients with Myotonic Dystrophy ; Abstract ; The Physiology of Neuromuscular Transmission ; Myotonic Pathophysiology from an Anaesthesiology Viewpoint ; Premedication |
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Induction of Anaesthesia Response to Muscle Relaxants ; Reverse of Neuromuscular Blockade ; Other Perioperative Triggers ; Management of Anaesthesia in Patients with Myotonic Dystrophy; Caesarean Section ; Scoliosis Surgery ; General Surgery ; Conclusion ; Acknowledgment ; Reference; Chapter 6 Functional Assessment and Rehabilitative Treatment in Myotonic Dystrophy Type 1 ; Abstract ; Introduction; 1. Functional Assessment ; 1.1. Muscle Strength; 1.2. Posture and Gait Abilities ; Clinical Evaluation: Muscle Efficiency ; Rehabilitative Treatment ; References |
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Chapter 7 Protein Kinase Inhibitors As Potential Therapeutic Agents to Ameliorate Pathogenesis of Myotonic Dystrophy Type 1 (DM1) Abstract ; Introduction; Toxicity of Mutant CUG Repeat RNA and Misregulation of Proteins in DM1 ; Therapeutic Approaches in DM1 ; Potential Mechanisms of Action of Small Molecule Kinase Inhibitors ; Conclusion ; Acknowledgments ; References ; Chapter 8 Variant Interrupted DMPK Alleles: Implications in the Pathogenesis and Molecular Diagnosis of Myotonic Dystrophy Type 1 (DM1) ; Abstract; Molecular Genetics of the DM1 Mutation |
Subject |
Myotonia atrophica -- Treatment.
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Myotonic Dystrophy -- therapy |
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Myotonie atrophique -- Traitement.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Added Author |
Jenkins, Sandra (Writer on Myotonic dystrophies), editor.
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Other Form: |
Print version: Myotonic dystrophies. New York : Nova Biomedical, [2015] 1634829050 (DLC) 2015939741 |
ISBN |
9781634829175 (ebook) |
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1634829174 |
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9781634829052 (hbk.) |
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1634829050 (hbk.) |
Standard No. |
AU@ 000062349985 |
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