| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Neuroscience research process
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Neurology--laboratory and clinical research developments
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| Bibliography |
Includes bibliographical references and index. |
| Note |
Print version record and cip data provided by publisher. |
| Contents |
NEUROLOGICAL DISORDERS ; NEUROLOGICAL DISORDERS ; Contents; Preface; Advanced Structural and Functional MRI Techniques in Parkinson's Disease; Abstract; Introduction; MR Morphometry; Diffusion MR Imaging; Functional MRI; Motor fMRI; Cognitive fMRI; Resting-State fMRI; Conclusion; References; Neuropoietic Cytokines and Neural Injury: Alterations in JAK2/STAT3 Signaling Associated with Aging; Abstract; 1. Introduction; 1.1. Neuropoietic Cytokine Family; 1.2. Role of the gp130 Cytokine Receptor Complex; 1.3. Role of Janus Kinases (Jaks) |
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1.4. Activation of Signal Transducer and Activator of Transcription 3 (STAT3)1.5. Effects of Phospho-STAT3 (pSTAT3); Cell Survival; Remodeling the Cellular Environment; Regulating Oxidative Stress; Immune Tolerance; Role of the Phosphorylation Site; 1.6. Regulating pSTAT3: Role of Negative Regulators; Suppressors of Cytokine Signaling (SOCS); Protein Inhibitors of Activated Stats (PIAS); Protein Tyrosine Phosphatases (PTP); 2. Discussion; 2.1. Changes in Neural Injury; Stroke; Traumatic Brain Injury; 2.2. JAK2/STAT3 Regulation Altered with Aging; 2.3. Significance of Phosphorylation Site. |
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3. Future Directions3.1. Elucidate the Role of STAT3 across Cell Types; 3.2. Modulating Beneficial vs. Detrimental Effects; 3.3. Identifying Injury-Associated Changes; 3.4. Understanding and Manipulating Regulatory Processes for Therapeutic Benefit; 3.5. The IL-6 and IL-10 Signaling Dynamic; 3.6. Therapeutic Development: Challenges of Inhibition; Conclusion; Acknowledgments; References; Neurological Complications Associated with Anti-Tumor Necrosis Factor Alpha (TNF-A) Treatment; Abstract; Introduction; Tumor Necrosis Factor (TNF)-A; Pathogenicity of TNF-A in Neurological Disorder. |
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Anti-TNF-A or TNF-A Antagonist DrugAnti-TNF-A and Neurological Disorders; Conclusion; References; Effect of Aging on Changes of Nociception and Cav2 1 Expression Patterns in Seven Inbred Mouse Strains; Abstract; Introduction; Materials and Methods; Animals; Nociceptive Assays; Statistical Analysis of Behavioral Tests; Real-Time qRT-PCR Analysis; Results; Pain-Related Behavioral Tests; Expression Tests of Cav2 Family Members with Real-Time qRT-PCR Assay; Discussion; Conclusion; Acknowledgments; References; Polymeric Intracorporeal Devices for the Management of Neurological Disorders. |
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Abstract1. Introduction; 2. Polymer-Based Implantable Devices for Major CNS Disorders; 2.1. Intracranial Implants; 2.1.1. Drug Delivery Approaches Employed to Traverse the Blood Brain Barrier; 2.1.1.1. Ethylene Vinyl Acetate Copolymers Avac as a Prototype; Biocompatible Polymer Employed for Local Drug Delivery to the Brain; 2.1.1.2. Silk-Based Polymers as an Alternative to Synthetic Drug Delivery-Systems for the Treatment of Epilepsy; 2.1.2. Application of Polymer-Based Implantable Devices in Parkinson's Disease; 2.1.2.1. Biocompatible Dopamine-Loaded Polymeric Matrix Device. |
| Subject |
Nervous system -- Diseases.
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Neurology.
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Nervous System Diseases |
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Neurology |
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Système nerveux -- Maladies.
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Neurologie.
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HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain)
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MEDICAL -- Neurology.
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Nervous system -- Diseases
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Neurology
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| Added Author |
Thomas, Chloe E., editor.
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Moore, Jayden R., editor.
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| Other Form: |
Print version: Neurological disorders. New York : Nova Biomedical, Science Science Publishers, Inc., [2012] 9781622570423 (DLC) 2012939016 |
| ISBN |
9781622570560 (ebook) |
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1622570561 |
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9781622570423 (hardcover) |
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1622570421 |
| Standard No. |
DEBBG BV041049537 |
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