Considerations for developing a dosimetry-based cumulative risk assessment approach for mixtures of environmental contaminants [electronic resource] / National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency.
Cincinnati, OH : National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 2007, released 2009.
Title taken from title screen (viewed April 8, 2009).
Mode of access: World Wide Web.
System requirements: Adobe Acrobat Reader.
[The report] addresses the justification for developing physiologically based pharmacokinetic (PBPK) models for cumulative risk assessment. Chemical interactions in the body can alter the response observed, but the likelihood of an interactions is often most dependent on exposure. Results from these models can explain the basis for chemical interactions and can predict their likelihood at low, environmental exposures. This report identifies some key points to be considered when deciding whether to use PBPK modeling in a cumulative risk assessment.