| Edition |
1st ed. |
| Description |
1 online resource (xiii, 291 pages) : illustrations |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
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text file |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Methods for preparation and physical properties of H-phosphonates -- Structure and spectral characteristics of H-phosphonates -- Reactivity of H-phosphonates -- Important classes of compounds -- Application of H-phosphonate diesters and their derivatives. |
| Summary |
Chemistry and Application of H-Phosphonates is an excellent source for those planning the synthesis of new phosphorus-containing compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of diesters of H-phosphonic acid makes them an excellent choice as synthone in a number of practically important reactions. Phosphonic acid esters are intermediates in the synthesis of important classes of compounds such as alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of each of these compound classes is reviewed in detail. Alpha-Aminophosphonic acids are an important class of biologically active compounds, which have received an increasing amount of attention because they are considered to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic agents are well documented. Alpha-Hydroxyalkanephosphonates are compounds of significant biological and medicinal applications. Dialkyl epoxyalkylphosphonates are of interest because of their use as intermediates in the synthesis of bioactive substances, and as modifiers of natural and synthetic polymers. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of drugs. Nucleoside H-phosphonates seem to be the most attractive candidates as starting materials in the chemical synthesis of DNA and RNA fragments. The 5-hydrogen phosphonate-3-azido-2,3-dideoxythimidine is one of the most significant anti-HIV prodrug, which is currently in clinical trials. Chapters review the synthesis; physical and spectral properties (<SUP>1</SUP>H, <SUP>13</SUP>C, <SUP>31</SUP>P and <SUP>17</SUP>O NMR data); characteristic reactions; important classes of compounds based on these esters of H-phosphonic acid; their application as physiologically active substances, flame retardants, catalysts, heat and light stabilizers, lubricants, scale inhibitors, polymer-carriers of drugs; preparation of H-phosphonate diesters and general procedures for conducting the most important reactions. * provides ideas for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds) * reviews structure, spectra and biological activity of H-phosphonates and their derivatives * examines new areas of application of phosphorus-containing compounds. |
| Note |
Print version record. |
| Language |
English. |
| Subject |
Phosphonates -- Physiological effect.
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Phosphonates -- Metabolism.
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Phosphonic acids -- Physiological effect.
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Phosphonic acids -- Metabolism.
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Phosphonates -- Effets physiologiques.
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Phosphonates -- Métabolisme.
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Acides phosphoniques -- Effets physiologiques.
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Acides phosphoniques -- Métabolisme.
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SCIENCE -- Chemistry -- Organic.
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Phosphonates -- Physiological effect
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Phosphonic acids -- Physiological effect
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| Other Form: |
Print version: Troev, Kolio D. (Kolio Dimov), 1944- Chemistry and application of H-phosphonates. 1st ed. Amsterdam ; Boston : Elsevier, 2006 0444527370 9780444527370 (DLC) 2006045694 (OCoLC)69672036 |
| ISBN |
9780444527370 |
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0444527370 |
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9780080476490 (electronic bk.) |
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008047649X (electronic bk.) |
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1281051160 |
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9781281051165 |
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9786611051167 |
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6611051163 |
| Standard No. |
AU@ 000060844863 |
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DEBBG BV039828729 |
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DEBBG BV042313949 |
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DEBSZ 367769662 |
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NZ1 12435183 |
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