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Title The handbook of metabonomics and metabolomics / edited by John C. Lindon, Jeremy K. Nicholson and Elaine Holmes.

Imprint Amsterdam ; Oxford : Elsevier, 2007.

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Location Call No. OPAC Message Status
 Axe Elsevier ScienceDirect Ebook  Electronic Book    ---  Available
Edition 1st ed.
Description 1 online resource (x, 561 pages) : illustrations (some color)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Summary Molecular biology operates at three levels genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies * aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification * covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.
Contents Chapter 1. Metabonomics and metabolomics techniques and their applications in mammalian systems. -- -- Chapter 2. Cellular metabolomics: the quest for pathway structure. -- -- Chapter 3. NMR spectroscopy techniques for application to metabonomics. -- -- Chapter 4. High-resolution magic angle spinning NMR spectroscopy. -- -- Chapter 5. Chromatographic and electrophoretic separations combined with mass spectrometry for metabonomics. -- -- Chapter 6. Chemometrics techniques for metabonomics. -- -- Chapter 7. Nonlinear chemometric methods for the analysis of metabolic profiles. -- -- Chapter 8. Databases and standardisation of reporting methods for metabolic studies. -- -- Chapter 9. Metabonomics in preclinical pharmaceutical discovery and development. -- -- Chapter 10. Metabolic applications in clinical pharmaceutical R & D. -- -- Chapter 11. Exploiting the potential of metabonomics in large population studies: three venues. -- -- Chapter 12. Metabolite profiling and cardiovascular disease. -- -- Chapter 13. The role of NMR-based metabolomics in cancer. -- -- Chapter 14. NMR spectroscopy of body fluids as a metabolomics approach to inborn errors of metabolism. -- -- Chapter 15. A survey of metabonomics approaches for disease characterisation. -- Chapter 16. Metabolic profiling: applications in plant science. -- -- Chapter 17. In vivo NMR applications of metabonomics. -- -- Chapter 18. Applications of metabonomics within environmental toxicology. -- -- Chapter 19. Global systems biology through integration of "omics" results.
Bibliography Includes bibliographical references and index.
Note Print version record.
Subject Molecular biology -- Technique -- Handbooks, manuals, etc.
Biochemistry -- Technique -- Handbooks, manuals, etc.
Gene expression -- Technique -- Handbooks, manuals, etc.
Metabolism.
Molecular genetics.
Biomolecules.
Gene expression.
Molecular Biology -- methods
Biochemistry -- methods
Gene Expression
Metabolism
Biologie moléculaire -- Technique -- Guides, manuels, etc.
Biochimie -- Technique -- Guides, manuels, etc.
Expression génique -- Technique -- Guides, manuels, etc.
Métabolisme.
Génétique moléculaire.
Biomolécules.
Expression génique.
metabolism (biological concept)
SCIENCE -- Life Sciences -- Biochemistry.
Gene expression
Biochemistry -- Technique
Biomolecules
Gene expression -- Technique
Metabolism
Molecular biology -- Technique
Molecular genetics
Chemische Analyse
Metabolit
Metabolom
Nachweis
Genre/Form Handbook
handbooks.
manuals (instructional materials)
Handbooks and manuals
Handbooks and manuals.
Guides et manuels.
Added Author Lindon, John C.
Nicholson, Jeremy K.
Holmes, Elaine.
Other Form: Print version: Handbook of metabonomics and metabolomics. 1st ed. Amsterdam ; Oxford : Elsevier, 2007 0444528415 9780444528414 (OCoLC)71347396
ISBN 9780444528414
0444528415
9780080468006 (electronic bk.)
0080468004 (electronic bk.)
Standard No. AU@ 000048129894
CHDSB 005985546
DEBBG BV039828469
DEBBG BV042304743
DEBSZ 405301200
DEBSZ 43037268X
NZ1 11778186
NZ1 15188728

 
    
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