| Description |
1 online resource (1 volume) |
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text rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Natural product drug discovery
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| Contents |
Cover -- Title -- Copyright -- Dedication -- Contents -- Contributors -- Editor's Biography -- Forewords -- Preface -- Chapter 1 -- Discovery and Development of Anti-Breast Cancer Agents From Natural Products: An Overview -- 1 -- Introduction -- 2 -- An overview of the book -- 2.1 -- Chapter 2 -- 2.2 -- Chapter 3 -- 2.3 -- Chapter 4 -- 2.4 -- Chapter 5 -- 2.5 -- Chapter 6 -- 2.6 -- Chapter 7 -- 2.7 -- Chapter 8 -- 2.8 -- Chapter 9 -- 2.9 -- Chapter 10 -- 2.10 -- Chapter 11 -- 3 -- Concluding remarks |
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Chapter 2 -- Epothilones A and B: The 16-Membered Natural Macrolides as a Fascinating Template for Antibreast Cancer Drug Di... -- 1 -- Introduction -- 2 -- Epothilones A and B: production and isolation, physical and spectral properties, anticancer potential, and mechanism of... -- 2.1 -- Production and isolation -- 2.2 -- Physical and spectral properties -- 2.2.1 -- Epothilone A (1) -- 2.2.2 -- Epothilone B (2) -- 2.3 -- Anticancer potential and mechanism of drug action -- 2.3.1 -- Anticancer potential -- 2.3.2 -- Mechanism of drug action -- 2.3.3 -- Structure-activity relationships (SARs) for epothilones |
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3 -- The epothilone template: role in anticancer drug discovery -- 4 -- Concluding remarks -- References -- Chapter 3 -- Anti-Breast Cancer Terpenoids of Natural Origins -- 1 -- Introduction -- 1.1 -- Causes of breast cancer -- 1.2 -- Types of breast cancers -- 1.3 -- Breast cancer biomarkers -- 1.4 -- Clinical diagnosis -- 1.5 -- Stages of breast cancer -- 1.6 -- Treatment options -- 2 -- Role of natural products in breast cancer treatment -- 2.1 -- Terpenes as anti-breast cancer agents -- 2.2 -- Sesquiterpenoids as anti-breast cancer agents -- 2.3 -- Diterpenoids as anti-breast cancer agents |
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2.3.1 -- Paclitaxel as a clinical drug against breast cancer -- 2.3.2 -- Structure-activity relationships (SARs) of paclitaxel -- 2.4 -- Triterpenoids as anti-breast cancer agents -- 2.4.1 -- Ursolic acid as anti-breast cancer agent -- 2.4.2 -- Cucurbitacins as anticancer agents against breast cancer -- 3 -- Future prospects -- 4 -- Concluding remarks -- Abbreviations -- References -- Chapter 4 -- Vinca Alkaloids as Chemotherapeutic Agents Against Breast Cancer -- 1 -- Introduction: an overview of breast cancer -- 2 -- Vinca alkaloids: general features, sources, and ethnopharmacological relevance |
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2.1 -- Vinblastine (originally known as vincaleucoblastine) -- 2.2 -- Vincristine (originally known as leurocristine) -- 2.3 -- Vinorelbine -- 2.4 -- Vindesine -- 2.5 -- Vinflunine -- 3 -- Isolation and characterization of vinca alkaloids -- 4 -- Mechanism of action of vinca alkaloids cytotoxicity -- 5 -- Preclinical studies: in vitro and animal research on the anti-breast activities of vinca alkaloids and its derivatives -- 6 -- Breast cancer clinical trials: the role of vinca alkaloids and derivatives -- 7 -- Commercial vinca alkaloids: pharmacokinetics, toxicity/adverse reactions and interactions |
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7.1 -- Pharmacokinetics |
| Subject |
Antineoplastic agents -- Development.
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Breast -- Cancer -- Chemotherapy.
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Natural products.
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Sein -- Cancer -- Chimiothérapie.
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Produits naturels.
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Antineoplastic agents -- Development
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Breast -- Cancer -- Chemotherapy
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Natural products
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| Added Author |
Brahmachari, Goutam, editor.
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| Other Form: |
Print version: 9780128212776 |
| ISBN |
0128212780 (ePub ebook) |
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9780128212783 (electronic bk.) |
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9780128212776 (pbk.) |
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0128212772 |
| Standard No. |
AU@ 000069611938 |
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UKMGB 020173463 |
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