| Description |
1 online resource (x, 90 pages) : illustrations |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Congenital disorders - laboratory and clinical research |
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Congenital disorders: laboratory and clinical research series.
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| Note |
Online resource; title from PDF title page (EBSCO, viewed August 12, 2015). |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
BICUSPID AORTIC VALVE: DIAGNOSIS, SURGICAL TREATMENT AND COMPLICATIONS -- BICUSPID AORTIC VALVE: DIAGNOSIS, SURGICAL TREATMENT AND COMPLICATIONS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter 1: Bicuspid Aortic Valve Syndrome: From the Etiology to the Surgical Strategies of Treatment -- Abstract -- Definition and Epidemiology of Aortic Pathology -- Etiopathogenesis of the Aortic Disease -- Histology of the Aortic Wall -- Anatomic Classification and Natural History -- Diagnosis -- Surgical Treatment -- Discussion -- References -- Chapter 2: Genetic Influences on Phenotype in Bicuspid Aortic Valve: Screening, Diagnosis and Prognosis -- Abstract -- Introduction -- Evidence for Heritability of BAV -- Normal Valve Development -- Animal Models of BAV -- Human Genetic Syndromes -- Linkage Analyses -- Target Gene Approach -- Next Generation Sequencing -- Genome-Wide Association Studies (GWAS) -- Genetic Basis of Thoracic Aortic Aneurysm (TAA) in BAV -- Thoracic Aortic Aneurysm Associated with BAV: Haemodynamic Theory -- Genotype-Phenotype Correlations -- Phenotype Modifiers -- Common Variants -- microRNAs: The New Kids on the Block -- State of Knowledge -- Conclusion -- Chapter 3: Genetic Basis, Pathogenesis and Histopathology of Aortopathy in Bicuspid Aortic Valve and Marfan syndrome -- Abstract -- Frequency and Possible Causes of Aortic Dilation (Aneurysms) -- Discussion -- Conclusion and Future Directions -- Acknowledgments -- References -- Index -- Blank Page. |
| Summary |
Bicuspid aortic valve (BAV) is the most common congenital pathology of the aortic valve occurring in 0.5-2% of the general population and frequently requiring surgical management after the fourth decade of life. From the etiology to the surgical management of BAV is analyzed. Other chapters review genome-wide association studies, linkage analyses and next-generation sequencing studies, which are beginning to build a more comprehensive picture of the genetic bases of BAV. The prospects for developing tools for genetic screening of families and for risk stratification are explored as well, including the future steps which are necessary for the creation of an individualized approach to managing BAV. The last chapter is a review of the present understanding of ascending thoracic aortic aneurysm pathogenesis. The genetic basis and basic pathology underlying BAV and ascending thoracic aortic aneurysms are discussed as well, and are compared to known mechanisms underlying other aortopathologies. |
| Subject |
Aortic valve -- Stenosis -- Surgery.
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Heart valve prosthesis.
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Cardiac catheterization.
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Heart Valve Prosthesis |
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Cardiac Catheterization |
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Aorte -- Rétrécissement -- Chirurgie.
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Prothèses valvulaires cardiaques.
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Cathétérisme cardiaque.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cardiac catheterization
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Heart valve prosthesis
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| Added Author |
Chapman, Anthony (Editor), editor.
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| ISBN |
9781634828093 (electronic bk.) |
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1634828097 (electronic bk.) |
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9781634827867 |
| Standard No. |
AU@ 000056951361 |
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