| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Bibliography |
Includes bibliographical references and index. |
| Summary |
Dehydroacetic acid (DHA) and its derivatives are a rich source of active compounds and have found broad applications in various fields due to their high chemical reactivity and physiological properties. Dehydroacetic Acid and Its Derivatives outlines the use of DHA and its derivatives for the synthesis of pharmacologically active heterocyclic compounds. Beginning with an introduction to the chemistry and reactivity of Dehydroacetic Acid, the book goes on to outline the key ring transformation reactions of DHA. The synthesis of various derivatives is then discussed, before a wide range of metal complexes of DHA are explored in detail. The book then concludes with a review of DHA's biological importance and its impressive range of pharmacological activities, including anti-cancer, anti-bacterial, anti-fungal and analgesic properties. For those researching the synthesis of bioactive heterocyclic compounds, Dehydroacetic Acid and Its Derivatives is a valuable guide conveying the fundamental knowledge needed to facilitate and enhance the successful synthesis of lead molecules. |
| Note |
Vendor-supplied metadata. |
| Contents |
Front Cover -- Dehydroacetic Acid and Its Derivatives -- Copyright Page -- Contents -- List of Contributors -- 1 Introduction -- 1.1 What Is Dehydroacetic Acid? -- 1.2 Chemistry of Dehydroacetic Acid -- 1.2.1 Constitution and Structure -- 1.2.2 Preparation of DHA -- 1.3 Reactivity -- 1.4 Reactions at C3, C4, C5, and C6 Positions of DHA -- 1.4.1 Reactions of Carbonyl Group at C3 -- 1.4.1.1 Synthesis of Pyrazoles -- 1.4.1.2 Formylation of DHA -- 1.4.1.3 Synthesis of Benzo/Benzopyrano Quinolizinines -- 1.4.1.4 Halogenation -- 1.4.1.5 Formation of Pyranopyran Diones -- 1.4.1.6 Lengthening of Carbonyl Chain -- 1.4.2 Reactions at C4 -- 1.4.2.1 Reactions With Nucleophiles -- 1.4.2.1.1 Synthesis of Mono and Dichloro Derivatives -- 1.4.2.1.2 Synthesis of Amino Pyrones and Methyl Ethers -- 1.4.3 Reactions at C5 -- 1.4.3.1 Synthesis of Benzhydryl Pyran-2-ones -- 1.4.3.2 Synthesis of Bromo Pyrones -- 1.4.3.3 Synthesis of Diazo Compounds -- 1.4.4 Reactions at C6 Position -- 1.4.4.1 Synthesis of Substituted Compounds of DHA at C6 Position -- 1.4.4.2 Synthesis of Unsaturated Pyrones -- 1.5 Other Reactions -- 1.5.1 Hydrogenation of the Ring -- 1.5.2 Deacetylation -- 1.5.3 Transformation Into Carbocyclic Systems -- 1.5.4 Formation of Metal Complexes -- 1.6 Applications -- 1.6.1 Synthetic -- 1.6.2 Biological -- 1.6.3 Industrial -- 1.6.4 Other Allied Uses -- 2 Ring Transformations in Dehydroacetic Acid -- 2.1 Synthesis of Various Pyrazoles -- 2.1.1 Synthesis of Amino Phenyl Ethanimidoyl Methyl Phenyl Pyrazololes -- 2.1.2 Synthesis of Hydroxy Phenyl Ethanimidoyl Methyl Phenyl Pyrazololes -- 2.1.3 Synthesis of 4-Pyrazolylpyrimidobenzimidazoles -- 2.1.4 Synthesis of Pyrazolones, Pyridopyrimidinone, Methylphenylpyrazololes -- 2.1.5 Synthesis of Pyrazolylidenethiazolopyrimidines -- 2.1.6 Synthesis of Pyrazolylpyridones -- 2.2 Synthesis of Bipyrazoles. |
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2.3 Isoxazoles, Pyrazolo-Pyrazoles, and Pyrazolones -- 2.4 Synthesis of Pyrazolo-Oxazin-2-Thione Compounds -- 2.5 Synthesis of Pyridones -- 2.6 Synthesis of Pyrano Pyridineolates -- 2.7 Synthesis of Pyridinol and Dimethyl Nicotinic Acid -- 2.8 Synthesis of Various Pyrimidines -- 2.9 Reactions That Modify the 2-Pyrone Skeleton -- 2.9.1 Synthesis of Various Substituted Pyrone by DHA Ring-Opening -- 2.9.2 Synthesis of Diones -- 2.9.3 Synthesis of 2,4,6-Triones -- 2.10 Synthesis of Benzodiazepine, Benzodiazepinone, and Bezimidazoles -- 3 Synthesis of Different Heterocyclic Compounds by Using DHA -- 3.1 Synthesis of Pyrazoles From Various Chalcones -- 3.2 Synthesis of Substituted 2H-Pyran-2-Ones -- 3.3 Synthesis of Various p-Tolylacryloyl Derivatives of DHA -- 3.4 Classical Procedure for Synthesis of Phenylimino Derivatives of DHA -- 3.4.1 Synthesis of Phenylimino Derivative of DHA Derivatives by Using the Ultrasound Promoted Method -- 3.5 Synthesis of DHA Substituted Thiazoles -- 3.6 Synthesis of Diazepines -- 3.6.1 Diazepines and Benzodiazepines -- 3.6.2 Benzodiazepines Synthesis by Using Bismuth (III) Catalysis -- 3.6.3 Benzothiazepines and Benzothiazines -- 3.6.3.1 1,5-Benzothiazepine (162) and 1,4-Benzothiazine (163) -- 3.7 Synthesis of Cinnamoyl Derivatives of DHA -- 3.7.1 Conventional Method -- 3.7.2 Microwave Method -- 3.8 Synthesis of Various DHA Derivatives by Using the Multicomponent Approach -- 3.8.1 Introduction -- 3.8.2 Imidazol Derivatives of DHA -- 3.8.3 Thiadiazine Derivatives of DHA -- 3.8.4 Thiazolyl-Pyrazolone Derivatives of DHA -- 3.8.5 Pyridine Derivatives of Dehydroacetic Acid via Hantzsch Reaction -- 4 Dehydroacetic Acid-Metal Complexes -- 4.1 Introduction and Importance of Fe Complexes -- 4.2 Importance of Pt Complexes -- 4.3 Importance of Cu Complexes -- 4.4 Importance of Ru and Zn Complexes. |
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4.5 Pd (II) and Ni (II) Chelates of DHA -- 4.6 Synthesis of Manganese Complexes From DHA -- 4.6.1 Mn(dha)2(CH3OH)2 X-Ray Crystal Structure -- 4.7 Synthesis of Ruthenium (II) and Ruthenium (III) Complexes With DHA -- 4.7.1 Synthesis of [RuCl (CO) (PPh3)2(L)] Complex -- 4.7.2 Synthesis of [RuCl2 (AsPh3)2L] -- 4.8 Synthesis of Cu (II), Co (II), Ni (II), and Cd (II) Complexes Using Sodium Salt of DHA -- 4.8.1 Synthesis of Mercaptotriazole Ligands -- 4.8.2 Synthesis of Cu (II) Mixed Ligand Complexes -- 4.8.3 Synthesis of Ni (II), Cd (II), and Co (II) Mixed Ligand Complexes -- 4.9 Synthesis of Fe (III), Ni (II), Cu (II), Co (II), Mn (II), and Complexes by Using o-Phenylenediamine, DHA, and p-Chloro ... -- 4.9.1 Synthesis of Ligand -- 4.9.2 Synthesis of Metal Complexes -- 4.10 Synthesis of Fe (III), Co (II), Ni (II), Mn (II), and Cu (II) Complexes by Using DHA, 4-Methyl-o-Phenylene Diamine, an ... -- 4.10.1 Synthesis of Metal Complexes -- 4.11 Synthesis of Mn (II), Co (II), Ni (II), and Cu (II) Complexes From Phenyl Aniline-DHA Ligand -- 4.11.1 Preparation of the Ligands -- 4.11.2 Preparation of Metal Complexes -- 4.12 Synthesis of Cr (III), Co (II), Oxo-Vanadium (IV), Mn (II), Fe (II), Cu (II), and Ni (II) Complexes From 1,2-Diaminoet ... -- 4.12.1 Synthesis of the Schiff Base (Ligand) -- 4.12.2 Preparation of the Metal Complexes -- 4.13 Synthesis of Ti (III), Cr (III), Fe (III), Mn (III), Zr (IV), VO (IV), and UO2 (VI) Complexes From DHA With 1,3-Diamin ... -- 4.13.1 Synthesis of H2L Ligand -- 4.14 Synthesis of Ni (II), Co (II) Complexes From Methanamine-DHA Ligand -- 4.14.1 Synthesis of Schiff Bases -- 4.15 Synthesis of Mo (V) Complexes Using EHMPB and Tryptamine -- 4.15.1 Synthesis of Ethyl Hydroxy Methyl Pyranyltryptamine Oxobutenoate Ligand (HL1) -- 4.15.2 Synthesis of Tryptaminoetylidene Methyl Pyrandione Ligand (HL2). |
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4.15.3 Synthesis of Di-oxodimolybdenum Complex [Mo2O4(L1)2(CH3OH)2] -- 4.15.4 Synthesis of Hexaoxohexamolybdate Complex (C10H12NH)[Mo6O12(OCH3)4(acac)3] -- 5 Various Biological Activities of DHA Derivatives -- 5.1 Introduction -- 5.2 Anti-HIV Activity -- 5.2.1 Antiviral Drugs -- 5.2.2 3-Acyl-4-Hydroxypyrones and Their Boron Difluoride Complexes as HIV-1 Integrase Inhibitors -- 5.3 Anticancer Activity -- 5.3.1 DHA-Hydrazone and its Zn (II), Ru (III), and Pd (II) Metal Complexes as Anticancer Agents -- 5.4 Antiliver Cancer Activity -- 5.4.1 Antibreast Cancer Activity -- 5.5 Antibacterial Activity -- 5.5.1 Different Heterocyclics From DHA Enaminone -- 5.5.2 4-Hydroxy-3-[(2E)-3-(4-Hydroxyphenyl) Prop-2-Enoyl]-6-Methyl-2H-Pyran-2-One (Ligand) and its Various Metal Complexes -- 5.5.3 Ruthenium Complexes of DHA -- 5.5.4 DHA Thiosemicarbazone and its Ruthenium Complexes -- 5.5.5 4-Hydroxy-3(1-{2-(Benzylideneamino)-Phenylimino}-Ethyl)-6-Methyl-2H-Pyran-2-One and its Complexes -- 5.5.6 Dichlorophenylimino Derivative of DHA -- 5.5.7 Chloro-Hydroxy-Methyl-Oxo-Pyranylethylideneacetohydrazide and its Metal Complexes -- 5.5.8 3-Cinnamoyl Derivatives of DHA -- 5.5.9 Hydroxynaphthalenylmethylene Aminophenyliminoethyl Derivative of DHA and its Metal Complexes -- 5.5.10 Hydroxynaphthalenylmethylene Aminophenyliminoethyl Derivative of DHA and its Lanthanide Metal Complexes -- 5.5.11 DHA Chalcones and Pyrazolines -- 5.5.12 4-Hydroxy-3-((E)-1-(4-((Z)-1-(2-Hydroxyphenyl) Ethylideneamino)-6-Methyl-1,3,5-Triazin-2-Ylimino)Ethyl)-6-Methyl-2H- ... -- 5.5.13 Pyrimidine Derivatives -- 5.5.14 2-Aminoethyl Ethane-1,2-Diamine Derivative of DHA and its Metal Complexes -- 5.5.15 Cyano Ethylidene Acetohydrazide Derivative of DHA and its Metal Complexes -- 5.5.16 Dichlorophenylimino Ethyl Derivative of DHA -- 5.5.17 Dihydroxyphenyl Derivative of DHA -- 5.6 Antifungal Activity. |
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5.6.1 3-/2-Aminophenylamine-(p-Toluoyl)-4-Hydroxy-6-(p-Tolyl)-2H-Pyrane-2-One and 4-Hydroxy-3-(p-Toluoyl)-6-(p-Tolil)-2H-Py ... -- 5.6.2 Ruthenium Chalconate Complexes -- 5.6.3 DHA and Ozonized Water on Pistachio Nuts -- 5.6.4 Hydroxyphenylpropenoylmethylpyran-2-One and its Copper Complex -- 5.6.5 DHA Thiosemicarbazone and its Ruthenium Complexes -- 5.6.6 3-((E)-1-(2-((E)-4-Chloro/Fluorobenzylideneamino)Phenylimino)Ethyl)-4-Hydroxy-6-Methyl-2H-Pyran-2-Ones (Ligands) and ... -- 5.6.7 DHA and its DHT, Br DHA Analogs -- 5.6.8 (E)-6-Methyl-3-(1-(Phenylimino)Ethyl)-2H-Pyran-2,4-Diol and its Metal Complexes -- 5.6.9 Chlorophenyl Substituted DHA -- 5.6.10 Azanediyl-bis-Ethanediyl-bis-Azanylylidene-Ethanylylidene-Hydroxyl Methyl Pyran-2-One Schiff Base and its Cu Metal C ... -- 5.7 Antiinflammatory Activity -- 5.7.1 Hydrazinyl DHA Derivatives and Pyranopyrazoles as Antiinflammatory Agents -- 5.8 Phytotoxic Activity -- 5.8.1 Enaminopyran-2,4-Dione as a Phytotoxic Agent -- 5.9 Analgesic Activity -- 5.9.1 Hydrazinyl DHA Derivatives and Pyranopyrazoles as Analgesic Agents -- 5.10 Photocleavage Activity -- 5.10.1 Benzohydrazide Derivative of DHA and its Ni (II), Co (II), and Cu (II) Metal Complexes -- 5.10.2 Cyanoacetohydrazide Derivative of DHA and its Metal Complexes -- References -- Index -- Back Cover. |
| Subject |
Heterocyclic compounds.
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Organic compounds -- Synthesis.
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Fungicides.
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Composés hétérocycliques.
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Composés organiques -- Synthèse.
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Fongicides.
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fungicide.
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SCIENCE -- Chemistry -- Organic.
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Fungicides
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Heterocyclic compounds
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Organic compounds -- Synthesis
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| Added Author |
Penta, Santhosh, editor.
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| Other Form: |
Print version: 0081019262 9780081019269 (OCoLC)978609640 |
| ISBN |
9780081019276 (electronic bk.) |
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0081019270 (electronic bk.) |
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9780081019269 |
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0081019262 |
| Standard No. |
AU@ 000059828352 |
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AU@ 000066135545 |
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UKMGB 018288706 |
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