| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Cancer etiology, diagnosis and treatments |
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Cancer etiology, diagnosis, and treatments.
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| Bibliography |
Includes bibliographical references and index. |
| Note |
Print version record. |
| Contents |
GASTROINTESTINAL STROMAL TUMORS IN ADULTS AND CHILDREN ; GASTROINTESTINAL STROMAL TUMORS IN ADULTS AND CHILDREN ; Library of Congress Cataloging-in-Publication Data; Contents; Forward; Preface; Chapter 1 Introduction to GIST: Epidemiology, Clinical Features and Diagnostic Work-up; Abstract; Epidemiology; History of GIST; Pathology; Mutation Status and Molecular Subtypes; KIT Mutations; PDGFRA Mutations; BRAF Mutations; SDH Deficiency; Wild Type GIST; Prognostic Factors; Clinical Features; Investigations; Treatment; Conclusion; References; Chapter 2 Molecular Genetics; Abstract |
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1. Introduction: Discovery of GIST Associated Genes2. Nonsyndromic GIST -- Genes and Their Oncogenic Mutations; 2.1. KIT and PDGFRA Genes, Protein Structure and Function; 2.2. Mutations in KIT and PDGFRA; 2.2.1. Familial GIST- Heritable KIT and PDGFRA Mutations; 2.2.2. Sporadic GIST- Primary KIT and PDGFRA Mutations; 2.3. PIK3CA, RAS, BRAF and SDHA Mutations; 2.3.1. BRAF Gene Mutations; 2.3.2. PIK3CA Gene Mutations; 2.3.3. KRAS Gene Mutations; 2.3.4. SDHA Gene Mutations; 2.4. Genotype -- Phenotype Correlations of KIT and PDGFRA Mutations in GIST Patients; 2.4.1. Pre-Imatinib Era |
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2.4.2. Post Imatinib Era2.4.3. Secondary Mutations in KIT and PGFRA and Imatinib Treatment Efficacy; 2.4.4. Sunitinib Efficacy in GIST Patients with KIT and PDGFRA Mutations; 2.4.5. Secondary Mutations in KIT and PGFRA and Imatinib Treatment Efficacy; 2.4.6. Association between Mutations in KIT and PDGFRA and Tumor Localization; 2.5. Other Genetic Changes Associated with GIST Progression; 3. Syndromic GIST -- Genes and Their Oncogenic Mutations; 3.1. Neurofibromatosis Type 1; 3.2. Carney Triad and Carney-Stratakis Syndrome; References; Chapter 3 Imaging of Gastrointestinal Stromal Tumours |
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AbstractNomenclature; Incidence; Presentation; Choice of Imaging Modalities; General Imaging Features; Site Specific Features; Oesophageal GIST; Gastric GIST; Small Bowel GIST; Colonic GIST; Anorectal GIST; GIST in the Mesentery and Omentum; GIST in the Retroperitoneum; Familial GIST and Association with Syndromes; Benign vs Malignant; Metastasis; Pediatric Gist; Evaluation of Response to Treatment; Conclusion; References; Chapter 4 Surgical Management of Gastrointestinal Stromal Tumors; Abstract; Introduction; Resectability; I. GIST 2-cm; A. Localized |
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Goals of Surgical TherapyMargin Status; Organ Sparing Surgeries; Role for Lymphadenectomy; Location Dictates Operation; B. Locally Advanced; C. Metastatic Disease; D. Symptomatic GIST; Conclusion; References; Chapter 5 Pathologic Diagnosis of Gastrointestinal Stromal Tumors; Abstract; Introduction; Pathogenesis; Diagnostic Specimens; Gross Appearance; Microscopic Appearance; Needle Aspiration Specimens; Immunohistochemistry; The Differential Diagnosis; Molecular Genetics; Prognosis; References; Chapter 6 Gastrointestinal Stromal Tumors in Younger Patients; Abstract; Introduction |
| Subject |
Gastrointestinal stromal tumors.
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Gastrointestinal stromal tumors -- Diagnosis.
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Gastrointestinal stromal tumors -- Treatment.
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Gastrointestinal Stromal Tumors |
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Tumeurs mésenchymateuses gastro-intestinales.
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Tumeurs mésenchymateuses gastro-intestinales -- Traitement.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Gastrointestinal stromal tumors
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| Added Author |
Ahmed, Atif Ali, editor.
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| Other Form: |
Print version: Gastrointestinal stromal tumors in adults and children. New York : Nova Biomedical, [2015] 9781634836791 (DLC) 2015948677 |
| ISBN |
9781634836982 (ebook) |
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1634836987 |
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9781634836791 (hbk.) |
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