First contacts with the Spanish and the Indians -- Carolinian expansion in the seventeenth centry -- The Mississippi question -- The southern frontier in Queen Anne's War -- The Charles Town Indian Trade -- Trade regulation and intercolonial problems -- The Yamasee War -- Defense and reconstruction -- Beginnings of British Western Policy -- The Carolina-Florida border -- International rivalries in the Old Southwest -- The board of trade and Southern Colonization -- The philanthropists and the genesis of Georgia.