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Title The MIF handbook / edited by Richard Bucala.

Imprint Singapore ; Hackensack, NJ. : World Scientific, ©2012.

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Location Call No. OPAC Message Status
 Axe EBSCO Clinical Nursing E-Book  Electronic Book    ---  Available
Description 1 online resource (viii, 390 pages) : illustrations
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Bibliography Includes bibliographical references and index.
Note Print version record.
Summary The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Contents Preface; Part I MIF Structure and Mechanism of Action; I-1 MIF, MIF Alleles, and the Regulation of the Host Response Richard Bucala; 1. Introduction; 2. MIF Gene; 3. MIF Production and Signal Transduction; 4. Innate Immunity; 5. Adaptive Immunity; 6. MIF Integrates Immune, Metabolic, and Oncogenic Responses; 7. MIF Alleles in Human Disease; 8. Therapeutic Implications and Future Directions; Acknowledgments; References; I-2 MIF and the Chemokine Axis Sandra Kraemer, Christian Weber and Jürgen Bernhagen; 1. Introduction; 2. Chemokines: Classes, Structure, Function, and Receptors.
3. Structural Classification of MIF4. Nonclassical MIF Secretion and Link to Secretion of CLF Chemokines; 5. Chemokine-like Function (CLF) Chemokines and MIF as a CLF Chemokine; 6. MIF/ Chemokine Receptor Interactions and Functional Role in Inflammation and Atherogenesis; 7. Structural Basis Underlying MIF/Chemokine Receptor Interactions; 8. MIF Receptor Complexes; 9. Conclusion; 10. Acknowledgments; References; I-3 CD74, the Natural Receptor for MIF, Regulates Cell Survival in Health and Disease Idit Shachar, Maya Gordin, Sivan Cohen, Inbal Binsky, Ayelet Marom and Shirly Becker-Herman.
1. Introduction2. CD74 (Invariant Chain, Ii); 3. CD74 Functions as a Chaperone for MHC Class II; 4. CD74 as a Signaling Molecule; 4.1 CD74 is a cell surface receptor that induces signaling cascades; 4.2 CD74 is subjected to regulated intramembrane proteolysis (RIP); 5. MIF Regulates B Cell Survival in a CD74-Dependent Manner; 5.1 A complex of CD74 and CD44 is essential for initiating the signaling cascade induced by MIF; 5.2 c-Met and its ligand HGF regulate mature B cell survival in a pathway induced by MIF binding to CD74/CD44.
5.3 MIF induces TAp63 expression, which regulates B cell survival in a CD74-dependent manner6. MIF Is Secreted from Perivascular Bone Marrow Dendritic Cell Clusters that Regulate B Cell Survival; 7. MIF and CD74 in Tumors; 7.1 MIF and CD74 in CLL survival; 7.2 MIF and CD74 regulate CLL homing to the BM; References; I-4 Towards the MIF Interactome Jörg Klug and Andreas Meinhardt; 1. Introduction; 2. MIF Affects Degradation of Regulatory Proteins by Modulating the Ubiquitin Proteasome System; 3. Ribosomal Protein S19 as Endogenous Inhibitor of Extracellular MIF.
Subject Cytokines.
Immune response -- Regulation.
Macrophages -- metabolism.
Macrophage Migration-Inhibitory Factors -- physiology.
Macrophage Activation.
Macrophage Migration-Inhibitory Factors -- genetics.
Macrophage Migration-Inhibitory Factors -- immunology.
Immune response -- Regulation.
Cytokines.
Medicine.
SCIENCE -- Life Sciences -- Biochemistry.
Cytokines. (OCoLC)fst00886268
Immune response -- Regulation. (OCoLC)fst00967872
Genre/Form Electronic books.
Electronic books.
Added Author Bucala, Richard.
Other Form: Print version: MIF handbook. Singapore ; Hackensack, NJ. : World Scientific, ©2012 9789814335355 (OCoLC)773023446
ISBN 9789814335362 (electronic bk.)
9814335363 (electronic bk.)
128359367X
9781283593670
9789814335355
9814335355
Standard No. AU@ 000053032873
AU@ 000055844746
DEBBG BV043139979
DEBBG BV044168098
DEBSZ 421359617
GBVCP 804108226

 
    
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