Online resource; title from PDF title page (EBSCO, Febrary 21, 2019).
Summary
Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R.
Contents
Mathematical Modeling Principles -- Model Parameter Estimation -- Modeling Influenza Virus Infection -- Modeling Ebola Virus Infection -- Modeling HIV Infection -- HIV Evolution During Treatment -- Optimal Therapy Scheduling -- Suboptimal Therapy Scheduling -- PK/PD-based Impulsive Control -- Bibliography -- Index.
