| Edition |
Second edition. |
| Description |
1 online resource (xxvi, 590 pages) : illustrations (some color) |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Oxford clinical nephrology series |
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Oxford clinical nephrology series.
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| Note |
Revised edition of: The spectrum of renal osteodystrophy / edited by Tilman Drüeke, Isidro B. Salusky. c2001. |
| Bibliography |
Includes bibliographical references and index. |
| Note |
Print version record. |
| Summary |
This new edition is fully updated to reflect the most current thinking and understanding in the field, as presented by a team of international clinical experts. |
| Contents |
Contributors; List of Abbreviations; Introduction; 1 Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD); Renal osteodystrophy; Chronic kidney disease-mineral bone disorder; Conclusion; References; 2 New aspects of normal bone biology; Introduction; Osteoclasts; Osteoblasts; Osteocytes; Systemic hormones; Summary; References; 3 Osteocytes and mineral metabolism; Introduction; The osteoblast/osteocyte lineage; Osteocyte role in mineralization; Roles of osteocytes in the control of Pi homeostasis |
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Osteocytes' role in phosphate dysregulation associated with CKDThe influence of CKD on osteocyte function; Summary; References; 4 Calcium-sensing receptors (CaSR) in kidney, bone, and vessels; Introduction; Expression, structure, and signaling of the extracellular CaSR; CaSR in the kidney; CaSR and bone; The CaSR and blood vessels; Summary; References; 5 Regulation of parathyroid hormone biosynthesis and gene expression; Introduction; Regulation of PTH expression by 1,25(OH)[sub(2)] vitamin D; Post-transcriptional regulation of PTH gene expression by calcium, phosphate, and CKD |
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Fibroblast growth factor-23 and PTH gene expressionConclusions; References; 6 Abnormal parathyroid gland function in CKD; Introduction; Regulation of PTH gene transcription in CKD; Regulation of PTH release in CKD; Phosphate and abnormal PTH synthesis and secretion in CKD; Vitamin D and abnormal PTH synthesis and secretion in CKD; Abnormal PTH synthesis and secretion due to other factors; Post-transcriptional modulation of PTH synthesis in CKD; Changes in the intracellular and peripheral metabolism of PTH in CKD; Hyperplasia of parathyroid glands in CKD |
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Parathyroid function and VDR polymorphismsControl of increased parathyroid mass; Parathyroid tissue apoptosis and necrosis; Summary; References; 7 PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor; Introduction; Characteristics of the PTHrP gene; Regulation of PTHrP production; Processing and degradation of PTHrP; Physiological actions of PTHrP; Mechanisms of action of PTHrP; PTH/PTHrP receptor expression in renal osteodystrophy; Summary; References; 8 Vitamin D metabolism and action in CKD; Introduction; 25-Hydroxyvitamin D deficiency in CKD; Calcitriol production in CKD |
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The vitamin D receptorEffects of declining 1,25-dihydroxyvitamin D on mineral metabolism; Non-traditional actions of vitamin D; Cardiac effects of calcitriol; Vitamin D and the immune system; Additional effects of vitamin D; Vitamin D and survival in CKD; Summary; References; 9 Growth factors and cytokines in renal bone disease; Introduction; The cells of bone; Bone remodeling; Effects of uremia on skeletal biology; References; 10 Bone histomorphometry in renal osteodystrophy; Historical perspective of renal osteodystrophy; Pathology of different forms of renal osteodystrophy |
| Language |
English. |
| Subject |
Renal osteodystrophy.
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Chronic Kidney Disease-Mineral and Bone Disorder |
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Renal Insufficiency, Chronic -- complications |
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Ostéodystrophie rénale.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Renal osteodystrophy
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Chronische Niereninsuffizienz
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Knochenstoffwechsel
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Mineralstoffwechselstörung
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| Added Author |
Olgaard, Klaus.
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Salusky, Isidro B.
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Silver, Justin, 1943-
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| Added Title |
Spectrum of renal osteodystrophy.
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| Other Form: |
Print version: Spectrum of mineral and bone disorders in chronic kidney disease. Second edition 9780199559176 (DLC) 2010286038 (OCoLC)520713073 |
| ISBN |
9780191029325 (electronic bk.) |
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0191029327 (electronic bk.) |
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0191753351 |
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9780191753350 |
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9780199559176 |
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0199559171 |
| Standard No. |
AU@ 000062489719 |
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AU@ 000062596274 |
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AU@ 000070742636 |
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DEBBG BV043032901 |
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DEBSZ 421221879 |
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GBVCP 813243963 |
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