Chapter 1: PATHOGENESIS OF PEMPHIGUS VULGARIS; ABSTRACT; INTRODUCTION; EPIDEMIOLOGY OF PEMPHIGUS VULGARIS; GENETICS; AUTOANTIGENS IN PEMPHIGUS VULGARIS; THE ROLE OF AUTOANTIBODIES; REGULATION OF PEMPHIGUS VULGARIS AUTOIMMUNITY; MOLECULAR MECHANISMS OF KERATINOCYTE DETACHMENT IN PEMPHIGUS VULGARIS; PREDICTORS OF COURSE AND PROGNOSIS IN PEMPHIGUS VULGARIS; CONCLUSION; Chapter 2: DIAGNOSTICS IN PEMPHIGUS VULGARIS; ABSTRACT.
INTRODUCTIONHISTOPATHOLOGY; DIRECT IMMUNOFLUORESCENCE MICROSCOPY; INDIRECT IMMUNOFLUORESCENCE MICROSCOPY; TARGET ANTIGEN-SPECIFIC SEROLOGICAL ANALYSES OF PEMPHIGUS ANTIBODIES; CONCLUSION; Chapter 3: CLINICAL CHARACTERISTICS OF PEMPHIGUS VULGARIS; ABSTRACT; INTRODUCTION; CLINICAL CHARACTERISTICS; CONCLUSION; Chapter 4: MANAGEMENT OF PEMPHIGUS VULGARIS; ABSTRACT; INTRODUCTION; MANAGEMENT OF PEMPHIGUS VULGARIS; CORTICOSTEROIDS; ADJUVANT DRUGS; CONCLUSION; REFERENCES; INDEX.
Summary
Pemphigus vulgaris (PV) is the most frequent condition inside the pemphigus group, especially in Europe and North America. It is the prototype of a genetically mediated disease. The HLA alleles associated with PV are well-known. Recent studies found an association between disease severity and some HLA DRB1 and DQB1 alleles. The author of this book discusses the management of PV that should be started with an evaluation of disease severity.