| Description |
1 online resource (289 pages) : color illustrations |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
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data file |
| Series |
Oxidative stress and dietary antioxidants
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| Summary |
Diabetes: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide among diabetologists, endocrinologists, and nutritionists in understanding and treating diabetes. The book covers, in a single volume, the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, receptor-mediated responses and more. This approach recognizes that diseases are usually multifactorial and that oxidative stress is a single component of this. Pharmacological treatments for diabetes are commonly marked by unwanted side effects, leading to treatment efforts using naturally occurring substances. But a plant-based approach alone is not sufficient; understanding the processes inherent in the oxidative stress of diabetes is vital for clinical workers, dietitians, and nutritionists. This translational work provides that understanding. The book begins by covering the basic biology of oxidative stress from molecular biology to imaging in relation to diabetes. There are chapters on neuropathy, nephropathy, atherosclerosis, cardiomyopathy, and retinopathy. The book then moves on to antioxidants in foods, including plants, components of the diet, and their relevance to diabetes.--Publisher. |
| Note |
Includes index. |
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Print version record. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Front Cover; Diabetes: Oxidative Stress and Dietary Antioxidants; Copyright; Contents; Preface; Contributors; Section I -- Oxidative Stress and Diabetes; Chapter 1 -- Oxidative Stress and Diabetic Neuropathy; INTRODUCTION AND EPIDEMIOLOGY; NATURAL HISTORY AND PROGNOSIS; HYPERGLYCEMIA AS A CRUCIAL CAUSE OF DIABETIC NEUROPATHY; OXIDATIVE STRESS AND DIABETIC NEUROPATHY; OXIDATIVE STRESS AND ANTIOXIDANT TREATMENT IN DIABETIC NEUROPATHY; THERAPEUTIC POTENTIAL OF A NEW ANTIOXIDANT PROTEIN DELIVERY IN DIABETIC NEUROPATHY. |
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FROM EXPERIMENTAL EVIDENCE OF NEUROPATHY IN ANIMALS TO THE TREATMENT OF DIABETIC NEUROPATHY IN MANCONCLUSION; SUMMARY POINTS; Acknowledgments; References; Chapter 2 -- Cerebral Ischemia in Diabetics and Oxidative Stress; INTRODUCTION -- DIABETES AND CEREBRAL ISCHEMIA; PATHOPHYSIOLOGICAL ROLES OF FREE RADICALS; DIABETES AND FREE RADICALS; CEREBRAL ISCHEMIA; FREE RADICAL PRODUCTION DURING ISCHEMIA/REPERFUSION; NOS PATHWAY; THE ROLE OF IRON; MITOCHONDRIAL PRODUCTION OF FREE RADICALS; REPERFUSION; FREE RADICALS AND CEREBRAL ISCHEMIA-INDUCED CELL DEATH PATHWAYS. |
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OXIDATIVE STRESS IN DIABETIC CEREBRAL ISCHEMIACONCLUSION; SUMMARY POINTS; References; Chapter 3 -- Diabetic Cardiomyopathy and Oxidative Stress; INTRODUCTION; DIABETIC CARDIOMYOPATHY; HALLMARKS OF DM; OXIDATIVE STRESS; HYPERGLYCEMIA; LIPOTOXICITY; ROS AND RNS IN DIABETIC CARDIOMYOPATHY; SUPEROXIDE; NITRIC OXIDE AND PEROXYNITRITE; HYDROXYL RADICAL; THE MODULATION OF CELL SIGNALING PATHWAYS; CONCLUSION; SUMMARY POINTS; References; Chapter 4 -- Diabetic Retinopathy and Oxidative Stress; HISTOPATHOLOGY OF DR; OXIDATIVE STRESS MECHANISMS; OXIDATIVE STRESS AND DR; SUMMARY POINTS; References. |
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Chapter 5 -- Mitochondrial Oxidative Stress in DiabetesINTRODUCTION; OXIDATIVE STRESS: ROS AND REACTIVE NITROGEN SPECIES (RNS); DIABETES; DIABETES, INFLAMMATION AND OXIDATIVE STRESS; ROS PRODUCTION AND DIABETIC COMPLICATIONS; ANTIOXIDANTS AND DIABETES; DIETARY ANTIOXIDANTS; ANTIOXIDANTS, MITOCHONDRIA AND DIABETES; CONCLUSIONS; SUMMARY POINTS; Acknowledgements; References; Chapter 6 -- Iron, Oxidative Stress and Diabetes; INTRODUCTION; DISTRIBUTION OF IRON IN THE BODY; IRON HOMEOSTASIS; OXIDATIVE STRESS; IRON AND OXIDATIVE STRESS; OXIDATIVE STRESS IN DIABETES; IRON AND DIABETES. |
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IRON OVERLOAD STATESIRON DEFICIENCY; THE ROLE OF IRON IN DIABETES WITHOUT OVERT IRON OVERLOAD; THE ROLE OF IRON IN COMPLICATIONS OF DIABETES; CONCLUSIONS; SUMMARY POINTS; References; Section II -- Antioxidants and Diabetes; Chapter 7 -- Ü-Tocopherol Supplementation, Lipid Profile, and Insulin Sensitivity in Diabetes Mellitus Type 2; INTRODUCTION; VITAMIN E AND DIABETES; A POSSIBLE MECHANISM UNDERLYING THE EFFECTS OF A-TOCOPHEROL IN DIABETES MELLITUS; A-TOCOPHEROL SUPPLEMENTATION IN TYPE 2 DIABETES MELLITUS; IS VITAMIN E SUPPLEMENTATION RECOMMENDED FOR DIABETIC COMPLICATIONS? |
| Language |
English. |
| Subject |
Diabetes -- Treatment.
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Diabetes.
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Oxidative stress.
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Diabetes Mellitus -- drug therapy |
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Antioxidants -- pharmacology |
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Antioxidants -- therapeutic use |
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Diabetes Mellitus -- etiology |
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Oxidative Stress -- drug effects |
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Oxidative Stress -- physiology |
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Diabetes Mellitus |
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Oxidative Stress |
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Medicine.
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Health & Biological Sciences.
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Clinical Endocrinology.
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Diabète.
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Stress oxydatif.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Oxidative stress
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Diabetes
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Diabetes -- Treatment
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Health and Wellbeing.
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| Added Author |
Preedy, Victor R.
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| Other Form: |
Print version: 9780124058859 |
| ISBN |
9780124055223 (electronic bk.) |
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0124055222 (electronic bk.) |
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9780124058859 |
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012405885X |
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9780124058859 |
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1306077907 |
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9781306077903 |
| Standard No. |
AU@ 000058028633 |
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AU@ 000059643685 |
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DEBBG BV043216086 |
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DEBBG BV044064660 |
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DEBSZ 405351968 |
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DEBSZ 481277013 |
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NZ1 15342322 |
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AU@ 000062431875 |
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AU@ 000060553557 |
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