| Description |
1 online resource (195 pages) |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Genetics--research and issues series |
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Genetics--research and issues series.
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| Bibliography |
Includes bibliographical references and index. |
| Note |
Online resource; title from PDF title page (ebrary, viewed November 9, 2013). |
| Summary |
Alternative splicing occurs in most human genes and contributes to protein diversity by producing multiple mRNAs from each gene. In this book, the authors present new developments in alternative splicing research. Topics discussed include alternative splicing alterations in Alzheimer's disease; plant RNA-binding proteins implicate mRNA processing in abscisic acid (ABA) responses; comprehensive analyses of alternative exons in neuronally differentiated P19 cells; an epigenetic view on alternative splicing; identification of genuine alternative splicing variants for rare or long-sized transcript. |
| Contents |
NEW DEVELOPMENTS IN ALTERNATIVE SPLICING RESEARCH; NEW DEVELOPMENTS IN ALTERNATIVE SPLICING RESEARCH; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: Alternative Splicing Alterations in Alzheimer's Disease; Abstract; Introduction; Conclusion; References; Chapter 2: Plant RNA-Binding Proteins Implicate mRNA Processing in Abscisic Acid (ABA) Responses; Abstract; 1. Introduction; 2. Splicing Factors; 3. Non-Splicing Proteins; Conclusion; References; Chapter 3: Comprehensive Analyses of Alternative Exons in Neuronally Differentiated P19 Cells; Abstract. |
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IntroductionMaterials and Methods; Results; Discussion; Acknowledgments; References; Chapter 4: An Epigenetic View on Alternative Splicing; Abstract; 1. Introduction; 2. Alternative Splicing and RNA Pol II Elongation Rate; 3. Nucleosomes and Alternative Splicing; 4. Chromatin Remodeling and Alternative Splicing; 5. Histone Post-Translational Modifications and Alternative Splicing; 6. Intragenic DNA Methylation and Alternative Splicing; Conclusion; References; Chapter 5: Identification of Genuine Alternative Splicing Variants for Rare or Long-Sized Transcripts; Abstract; 1. Introduction. |
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2. Synthesis of Full-Length cDNA Using the Vector-Capping Method3. Analysis of Full-Length cDNA Clones; 4. Full-Length cDNA Libraries Derived from Other Species; 5. Problems on Identification of AS Variants; Conclusion; References; Chapter 6: Alternative RNA Splicing and Regulation of Nitric Oxide Signaling; Abstract; Abbreviations; Introduction; NO/cGMP Pathway and Its Role in Physiology; Neuronal Nitric Oxide Synthase (nNOS); Endothelial Nitric Oxide Synthase (eNOS); NO-Inducible Heterodimeric Soluble Guanylyl Cyclase (sGC); cGMP-Dependent Protein Kinase G (PKGI) |
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Cyclic Nucleotide Gated Ion Channels (CNGCs)Conclusion; References; Chapter 7: Alternative Splicing by Analyzing a Human mRNA Diversity Using Data of FLJ Human cDNAs; Abstract; Introduction; Identification of Transcription Products Produced by Variety of Tne Human mRNA; Construction of the Custom DNA Microarray for Analysis of mRNA Variation; Analysis of Alternative Splicing Using NT2 CellsInduced Neuronal Differentiation by Retinoic Acid; Analysis of Relationship between mRNA Variation by Alternative Splicing and the Gene Function; Conclusion; References. |
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Chapter 8: Alternative Splicing in Human Immune System and Autoimmune DiseasesAbstract; Alternative Splicing and Immune Cell Function; Alternative Splicing and Cytokine Response; Dysregulated Splicing in Autoimmune Diseases; Conclusion; References; Chapter 9: Poly(ADP-Ribosyl)ation Regulates Alternative Splicing; Abstract; Introduction; 1. Regulation of Alternative Splicing by PARylation; 2. Regulation of Splicing by PARP1 during the Transcription Process; 3. Perspectives; Acknowledgments; References; Index. |
| Subject |
Genetic polymorphisms.
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RNA splicing.
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RNA Splicing |
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Polymorphism, Genetic |
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Polymorphisme génétique.
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Épissage.
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PHILOSOPHY -- History & Surveys -- Modern.
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Genetic polymorphisms
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RNA splicing
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| Added Author |
DiMaggio, Samuel.
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Braschi, Emma.
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| Other Form: |
Print version: New developments in alternative splicing research. 9781628087208 (OCoLC)854139854 |
| ISBN |
9781628087215 (electronic bk.) |
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1628087218 (electronic bk.) |
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9781628087208 |
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162808720X |
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9781628087208 |
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