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Author Laplane, Lucie, 1984- author.

Title Cancer stem cells : philosophy and therapies / Lucie Laplane.

Publication Info. Cambridge, Massachusetts : Harvard University Press, 2016.


Location Call No. OPAC Message Status
 Axe EBSCO Clinical Nursing E-Book  Electronic Book    ---  Available
Description 1 online resource (x, 252 pages) : illustrations
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Bibliography Includes bibliographical references and index.
Contents Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer?
Summary "An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher.
Note Print version record.
Subject Cancer cells.
Stem cells.
Cancer -- Treatment -- Philosophy.
Neoplastic Stem Cells.
Stem Cells.
Neoplasms -- therapy.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
SCIENCE / Life Sciences / Cell Biology
Cancer cells. (OCoLC)fst00845563
Cancer -- Treatment -- Philosophy. (OCoLC)fst00845550
Oncology. (OCoLC)fst01045739
Stem cells. (OCoLC)fst01132975
Genre/Form Electronic books.
Electronic books.
Other Form: Print version: Laplane, Lucie, 1984- Cancer stem cells. Cambridge, Massachusetts : Harvard University Press, 2016 9780674088740 (DLC) 2015042054 (OCoLC)926061404
ISBN 9780674969582 (electronic bk.)
0674969588 (electronic bk.)
Standard No. AU@ 000062358839

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