| Edition |
First edition. |
| Description |
1 online resource (xii, 176 pages) : illustrations (some colour) |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Annual reports in medicinal chemistry, 0065-7743 ; volume 52 |
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Annual reports in medicinal chemistry ; v. 52.
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| Bibliography |
Includes bibliographical references. |
| Contents |
Preface / Kelly Chibale -- Chapter One. Tuberculosis / Steven J. Berthel, Christopher B. Cooper, Nader Fotouhi -- Chapter Two. Antituberculosis agents: beyond medicinal chemistry rules / Marco Pieroni -- Chapter Three. Development of MmpL3 inhibitors for tuberculosis treatment / Giovanna Poce, Sara Consalvi, Giulia Venditti, Cristina Scarpecci, Mariangela Biava -- Chapter Four. Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis / Andrew M. Thompson, William A. Denny -- Chapter Five. Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance / Nicolas Willand, Marion Flipo, Baptiste Villemagne, Alain Baulard, Benoit Deprez -- Chapter Six. Sustainable anti-trypanosomatid drugs: an aspirational goal for medicinal chemistry / Maria Laura Bolognesi. |
| Summary |
"Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated"--Publisher's web page, viewed September 6, 2019 |
| Note |
Online resource; title from publisher's web page (ScienceDirect, viewed September 6, 2019) |
| Subject |
Antitubercular agents -- Development.
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Drug development.
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Pharmaceutical chemistry.
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Tuberculosis.
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Mycobacterium tuberculosis.
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Trypanosomiasis.
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Chemistry, Pharmaceutical |
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Mycobacterium tuberculosis |
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Trypanosomiasis |
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Antituberculeux -- Développement.
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Médicaments -- Développement.
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Chimie pharmaceutique.
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Tuberculose.
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Mycobacterium tuberculosis.
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Trypanosomiase.
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Drug development
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Mycobacterium tuberculosis
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Pharmaceutical chemistry
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Trypanosomiasis
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Tuberculosis
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| Added Author |
Chibale, Kelly, editor.
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| Other Form: |
Print version: Medicinal chemistry approaches to tuberculosis and trypanosomiasis. First edition. Elsevier Academic Press, 2019 9780128175569 |
| ISBN |
9780128175569 (hardcover) |
| Standard No. |
AU@ 000066127945 |
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