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Electronic Book
Author Hagel, Lars.

Title Handbook of process chromatography : development, manufacturing, validation and economics.

Imprint London ; Burlington, MA : Academic, 2008.

Copies

Location Call No. OPAC Message Status
 Axe Elsevier ScienceDirect Ebook  Electronic Book    ---  Available
Edition 2nd ed. / Lars Hagel, Günter Jagschies and Gail Sofer.
Description 1 online resource (xvi, 363 pages) : illustrations
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Summary This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design.
Contents Preface -- Acknowledgements -- 1. Biopharmaceuticals Today -- 2. Process Capability and Production Scenarios -- 3. Process Design Concepts -- 4. Separation Technologies -- 5. Analysis -- 6. Cleaning and Sanitization -- 7. Validation -- 8. Economics -- 9. Basic Properties of Peptides, Proteons, Nucleic Acids, and Virus Particles -- 10. Optimization of Chromatographic Separations -- 11. Equipment -- 12. Column Packing -- Appendix A. Symbols and Definitions in Liquid Chromatography -- Appendix B. Dimensionless Numbers -- Appendix C. Activities for Biopharmaceutical Production from Genetically Engineered Mammalian Cells -- Appendix D. Simulations Using the Supplied Software.
Note Previous edition: published as by G.K. Sofer and Lars Hagel. 1997.
Includes CD-ROM.
Bibliography Includes bibliographical references and index.
Note Print version record.
Subject Chromatographic analysis -- Industrial applications.
Chromatographie -- Applications industrielles.
Chromatographic analysis -- Industrial applications
Added Author Jagschies, Günter.
Sofer, G. K.
Other Form: Print version: Hagel, Lars. Handbook of process chromatography. 2nd ed. London ; Burlington, MA : Academic, 2008 9780123740236 0123740231 (OCoLC)181420871
ISBN 9780123740236
0123740231
0080554512 (electronic bk.)
9780080554518 (electronic bk.)
9780123741875 (computer optical disc)
0123741874 (computer optical disc)
Standard No. AU@ 000043178384
CDX 6610035
CHDSB 005985667
DEBBG BV039829345
DEBBG BV042305671
DEBSZ 367767252
NZ1 12541529
NZ1 15189589
AU@ 000075306904

 
    
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