| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Advances in magnetic resonance technology and applications ; v. 3 |
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Advances in magnetic resonance technology and applications ; v. 3.
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| Note |
Print version record. |
| Contents |
Front Cover -- HYPERPOLARIZED CARBON-13 MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY -- HYPERPOLARIZED CARBON-13 MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY -- Copyright -- Series list -- Contents -- Contributors -- Preface -- Organization -- Prerequisites -- Acknowledgments -- 1 -- The physics of dissolution Dynamic Nuclear Polarization -- 1.1 Introduction -- 1.2 Polarization, magnetization, sensitivity, and hyperpolarization -- 1.3 Methods of hyperpolarization -- 1.4 Dynamic Nuclear Polarization -- 1.4.1 Solid effect -- 1.4.2 Cross-effect and thermal mixing |
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1.5 The DNP sample: formulation of the imaging agent and the electron paramagnetic agent -- 1.6 Dissolution and relaxation -- 1.7 Conclusion -- References -- 2 -- Hardware for preparing HP 13C-molecules: from polarizer to patient -- 2.1 Requirements for DNP -- 2.1.1 The magnet -- 2.1.2 Cryogenic environment -- 2.1.3 Microwaves -- 2.1.4 The sample -- 2.2 Monitoring of solid-state 13C polarization -- 2.3 Rapid state change -- 2.4 Preclinical dDNP -- 2.5 Postdissolution -- 2.6 Clinical dDNP -- 2.6.1 Quality control -- 2.7 Future developments -- 2.8 Conclusions -- Acknowledgments -- References |
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3 -- HP acquisition methods: pulse sequences, reconstruction, and RF coils -- 3.1 Introduction -- 3.2 Hyperpolarized imaging considerations -- 3.2.1 T1 decay and nonrecoverable magnetization -- 3.2.2 RF decay and metabolism -- 3.2.3 Chemical shift displacement -- 3.3 Pulse sequences and reconstruction -- 3.3.1 Nonselective spectroscopy and CSI -- 3.3.2 Fast spectroscopic imaging -- 3.3.3 IDEAL CSI -- 3.3.4 Metabolite-selective imaging -- 3.3.5 Pulse sequence summary -- 3.4 RF coils -- 3.4.1 Surface and volume coils -- 3.4.2 Multichannel arrays and coil combination -- 3.5 Summary -- References |
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4 -- HP experimental methods: cells and animals -- 4.1 Introduction -- 4.2 Dissolution-What is in it? -- 4.3 Transfer to the magnet-how fast can you run? -- 4.4 Delivery-how much and how to? -- 4.4.1 How much of the hyperpolarized agent is sufficient? -- 4.4.2 How to deliver the hyperpolarized agent? -- 4.5 Preclinical model systems for testing of hyperpolarized 13C agents -- 4.5.1 Models used for feasibility testing -- 4.5.2 Models used for HP agent development for a predetermined biomedical application -- 4.5.3 Preclinical animal models used in hyperpolarized NMR |
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4.6 Understanding and interpreting the hyperpolarized signals to shed light on the underlying biochemistry of the pathology -- Acknowledgments -- References -- Further study -- 5 -- HP agents and biochemical interactions -- 5.1 Introduction -- 5.1.1 Main differences between 1H MRI and HP 13C spectroscopy and imaging -- 5.1.2 Ideal characteristics of an HP 13C agent -- 5.1.3 Carbon-13 magnetic resonance and labeled metabolic substrates -- 5.2 Overview of biological HP agents -- 5.2.1 [1-13C]pyruvate -- 5.2.2 [1,4-13C2]Fumarate -- 5.2.3 Carbohydrates -- 5.2.4 Fatty acids and ketone bodies |
| Subject |
Magnetic resonance imaging.
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Electron paramagnetic resonance.
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Magnetic Resonance Imaging |
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Imagerie par résonance magnétique.
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Résonance paramagnétique électronique.
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electron spin resonance.
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Electron paramagnetic resonance
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Magnetic resonance imaging
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| Added Author |
Larson, Peder E. Z., editor.
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| Other Form: |
Print version: Hyperpolarized carbon-13 magnetic resonance imaging and spectroscopy. [Place of publication not identified] : Academic Press, 2021 0128222697 (OCoLC)1220992820 |
| ISBN |
9780128222706 (electronic bk.) |
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0128222700 (electronic bk.) |
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9780128222690 |
| Standard No. |
AU@ 000070497078 |
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UKMGB 020327945 |
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