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1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Summary |
Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of "meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction |
| Note |
Includes index. |
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Online resource; title from PDF title page (ScienceDirect, viewed June 10, 2016). |
| Contents |
Title page; Table of Contents; Copyright; List of Contributors; Preface; Chapter One. A Free Radical Primer; Abstract; 1.1 Free Radical Biology-Importance; 1.2 RED/OX Chemistry; 1.3 Biological Oxidation Events; 1.4 Conclusion and Final Thoughts; References; Chapter Two. Oxidative Stress, Inflammation, and Disease; Abstract; 2.1 Introduction; 2.2 ROS and Oxidative Stress: A Major Activator of Inflammatory Pathways; 2.3 Inflammation: A Major Cause of Oxidative Stress; 2.4 Oxidant Stress and Inflammation in Cellular Transformation, Apoptosis, and Necrosis |
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2.5 Exploring the Link Between Oxidative Stress and Inflammation and the Onset of Various Diseases2.6 Antioxidants and Anti-Inflammatory Agents: Perspectives in Therapeutics; 2.7 Conclusions and Perspectives; Abbreviations; References; Chapter Three. Oxidative Stress, Inflammation, and the Corrosion of Metallic Biomaterials: Corrosion Causes Biology and Biology Causes Corrosion; Abstract; 3.1 Introduction; 3.2 Oxidation, Reduction, and Tribocorrosion at Metallic Biomaterial Surfaces; 3.3 Immune Cells, Inflammation, and ROS; 3.4 Metal Ions and Wear Debris Effects on Local Tissues |
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3.5 Reduction Reactions and Cellular Viability3.6 ICIC of CoCrMo and Ti Alloys: ROS Effects on Corrosion and Wear; 3.7 Summary and Conclusions; Acknowledgments; References; Chapter Four. Oxidative Stress and Biomaterials: The Inflammatory Link; Abstract; 4.1 Introduction; 4.2 FBR to Biomaterials; 4.3 Effect of Physicochemical Properties of Biomaterial on Inflammation; 4.4 Relationship between Inflammation and Oxidative Stress; 4.5 Oxidative Stress as By-Product of Inflammatory Response to Biomaterial; 4.6 Impact of Oxidative Stress on Implanted Cells and Induction of Inflammation |
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4.7 ConclusionReferenceS; Chapter Five. Nanoparticle Toxicity and Environmental Impact; Abstract; 5.1 Introduction; 5.2 Nanotoxicology; 5.3 Free Radicals, Reactive Oxygen Species, and Oxidative Stress; 5.4 Nanoparticle-Induced ROS Generation and Oxidative Stress; 5.5 Inflammation and Nanoparticles; 5.6 Systemic Toxicity; 5.7 Mechanisms of Nanoparticle Toxicity; 5.8 Genotoxic Effects of Nanoparticles; 5.9 Ecotoxicity of Nanoparticles and Its Environmental Impact; 5.10 Conclusion; Acknowledgments; References; Chapter Six. In Vitro Cellular Assays for Oxidative Stress and Biomaterial Response |
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Abstract6.1 Introduction to the In Vitro Cellular Assays; 6.2 Choice of Cell Lines and Animal Models; 6.3 "Real-Time" Cellular Assays for Detection of Oxidative Stress; 6.4 Fluorescent Probes and Dyes Based Detections; 6.5 Seahorse FX Technology Based Assays; 6.6 EPR Methods; 6.7 "Static" Assays for Detection of Oxidative Stress; 6.8 Conclusion; Abbreviations; References; Chapter Seven. Redox Interactions Between Nanomaterials and Biological Systems; Abstract; 7.1 Introduction; 7.2 Oxidative Stress by Inorganic Nanomaterials; 7.3 Oxidative Stress by Organic Nanomaterials |
| Bibliography |
Includes bibliographical references and index. |
| Subject |
Biomedical materials -- Biocompatibility.
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Oxidative stress.
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Biomedical materials.
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Biocompatible Materials |
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Oxidative Stress |
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Biomedical and Dental Materials |
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Biomatériaux -- Biocompatibilité.
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Stress oxydatif.
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Biomatériaux.
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HEALTH & FITNESS -- Holism.
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HEALTH & FITNESS -- Reference.
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MEDICAL -- Alternative Medicine.
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MEDICAL -- Atlases.
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MEDICAL -- Essays.
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MEDICAL -- Family & General Practice.
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MEDICAL -- Holistic Medicine.
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MEDICAL -- Osteopathy.
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Biomedical materials
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Biomedical materials -- Biocompatibility
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Oxidative stress
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| Added Author |
Dziubla, Thomas, editor.
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Butterfield, D. Allan, editor.
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| Other Form: |
Print version: 0128032693 9780128032695 (OCoLC)938383040 |
| ISBN |
9780128032701 (electronic bk.) |
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0128032707 (electronic bk.) |
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9780128032695 |
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0128032693 |
| Standard No. |
AU@ 000058965882 |
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DEBSZ 482471352 |
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GBVCP 879396520 |
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UKMGB 017975371 |
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AU@ 000068464148 |
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