| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Profiles of Drug Substances, Excipients and Related Methodology, 1871-5125 ; Volume 40 |
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Profiles of drug substances, excipients, and related methodology ; Volume 40.
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| Summary |
Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. |
| Note |
Includes index. |
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Print version record. |
| Bibliography |
Includes bibliographical references at the end of each chapters and index. |
| Contents |
Front Cover; Profiles of Drug Substances, Excipients, and Related Methodology; Copyright; Contents; Preface to Volume 40; Chapter 1: Cinnarizine: Comprehensive Profile; 1. Description; 1.1. Nomenclature; 1.1.1. Systemic Chemical Names; 1.1.2. Nonproprietary Names; 1.1.3. Proprietary Names; 1.1.3.1. Cinnarizine; 1.1.3.2. Cinnarizine Hydrochloride; 1.1.3.3. Mixture with Vitamin B6; 1.2. Formulae; 1.2.1. Empirical Formula, Molecular Weight, and CAS Number; 1.2.2. Structural Formulae; 1.3. Elemental Analysis; 1.4. Appearance; 1.5. Uses and Applications; 2. Methods of Preparation. |
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3. Physical Characteristics3.1. Ionization Constant; 3.2. Solubility Characteristics; 3.3. X-Ray Powder Diffraction Pattern; 3.4. Thermal Method of Analysis; 3.4.1. Melting Behavior; 3.5. Spectroscopy; 3.5.1. Ultraviolet Spectroscopy; 3.5.2. Vibrational Spectroscopy; 3.5.3. Nuclear Magnetic Resonance Spectrometry; 3.5.3.1. 1H NMR Spectrum; 3.5.3.2. 13C NMR Spectrum; 3.5.4. Electron Impact Mass Spectrometry; 4. Methods of Analysis; 4.1. Compendial Methods; 4.1.1. British Pharmacopoeial Methods [9]; 4.1.1.1. Identification; 4.1.1.2. Tests; 4.1.1.3. Acidity or Alkalinity; 4.1.1.4. Loss on Drying. |
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4.1.1.5. Heavy Metals4.1.1.6. Sulfated Ash; 4.1.1.7. Assay; 4.1.1.8. Storage; 4.1.1.9. Impurities; 4.2. Reported Methods of Analysis; 4.2.1. Titrimetric Method; 4.2.2. Spectrophotometric Methods; 4.2.2.1. Ultraviolet Spectrometry; 4.2.2.2. Spectrofluorimetric Method; 4.2.2.3. Chemiluminescence Method; 4.2.3. Voltammetric Methods; 4.2.4. Polarographic Method; 4.2.5. Chromatographic Methods; 4.2.5.1. Thin-Layer Chromatography; 4.2.5.2. Gas Chromatography; 4.2.5.3. Gas Chromatography-Mass Spectrometric Method; 4.2.5.4. High-Performance Liquid Chromatographic Methods. |
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4.2.5.5. High-Performance Liquid Chromatography-Mass Spectrometry4.2.5.6. Capillary Electrophoresis; 5. Biological Analysis; 6. Stability; 7. Pharmacokinetics, Metabolism, and Excretion; 8. Pharmacology; Acknowledgment; References; Chapter 2: Glutathione; 1. Description; 1.1. Nomenclature; 1.1.1. Systematical Chemical Names; 1.1.2. Nonproprietary Name; 1.1.3. Proprietary Names; 1.2. Formulae; 1.2.1. Empirical Formula, Molecular Weight, and CAS Number; 1.2.2. Structural Formula; 1.3. Elemental Composition; 1.4. Appearance; 2. Uses and Applications; 3. Methods of Preparation. |
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3.1. History of Glutathione Structure[12]3.2. Biosynthesis of Glutathione; 3.3. Synthesis of Glutathione; 3.3.1. First Method; 3.3.2. Second Method; 4. Physical Characteristics; 4.1. Solubility; 4.2. X-ray Powder Diffraction Pattern; 4.3. Crystal Structure; 4.3.1. Determination of the Positions of the Sulfur Atoms in the Unit Cell; 4.3.2. The Cochran and Douglas Method [33] Applied to the c-Axis Projection; 4.3.3. The Use of the Heavy-Atom Technique; 4.3.4. The Refinement of the Structure; 4.4. Thermal Methods of Analysis; 4.4.1. Melting Behavior; 4.4.2. Differential Scanning Calorimetry. |
| Language |
English. |
| Subject |
Drugs.
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Excipients.
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Pharmaceutical Preparations |
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Excipients |
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Pharmaceutical Vehicles |
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Médicaments.
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Excipients.
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MEDICAL -- Pharmacology.
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Drugs
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Excipients
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| Added Author |
Brittain, H. G., editor.
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| Added Title |
Profiles of drug substances, excipients and related methodology. Volume 40 |
| Other Form: |
Print version: Profiles of drug substances, excipients and related methodology. Volume forty. First edition. Amsterdam, Netherlands : Academic Press, ©2015 xii, 501 pages Profiles of drug substances, excipients, and related methodology ; Volume 40 1871-5125 9780128033005 |
| ISBN |
9780128033739 (electronic bk.) |
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0128033738 (electronic bk.) |
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9780128033005 |
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0128033002 |
| Standard No. |
AU@ 000056101129 |
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AU@ 000067085483 |
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AU@ 000068485641 |
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CHBIS 010550029 |
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CHVBK 34193142X |
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GBVCP 879384174 |
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UKMGB 017391514 |
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